Jaume Mora

Research interests

Publications

• Sarcoma classification by DNA methylation profiling

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-020-20603-4

• Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program

  Acta Neuropathologica · 2019 · https://doi.org/10.1007/s00401-019-02062-4

• Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms

  Nature Medicine · 2019 · https://doi.org/10.1038/s41591-019-0653-6

• Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features

  Acta Neuropathologica · 2018 · https://doi.org/10.1007/s00401-018-1865-4

• Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

  Science · 2018 · https://doi.org/10.1126/science.aao4750

• Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells

  Nature Medicine · 2018 · https://doi.org/10.1038/s41591-018-0086-7

• EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

  Cancer Cell · 2018 · https://doi.org/10.1016/j.ccell.2017.12.009

• Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma

  Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.08.017

• Intertumoral Heterogeneity within Medulloblastoma Subgroups

  Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.05.005

• The whole-genome landscape of medulloblastoma subtypes

  Nature · 2017 · https://doi.org/10.1038/nature22973

• EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

  Nature Medicine · 2017 · https://doi.org/10.1038/nm.4293

• Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

  Journal of Clinical Oncology · 2016 · https://doi.org/10.1200/jco.2015.65.7825

• Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.02.001

• Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

  The Lancet Oncology · 2016 · https://doi.org/10.1016/s1470-2045(15)00581-1

• Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

  Proceedings of the National Academy of Sciences · 2014 · https://doi.org/10.1073/pnas.1419260111

• Cytogenetic Prognostication Within Medulloblastoma Subgroups

  Journal of Clinical Oncology · 2014 · https://doi.org/10.1200/jco.2013.50.9539

• Comprehensive Genomic Analysis of Rhabdomyosarcoma Reveals a Landscape of Alterations Affecting a Common Genetic Axis in Fusion-Positive and Fusion-Negative Tumors

  Cancer Discovery · 2014 · https://doi.org/10.1158/2159-8290.cd-13-0639

• The Genomic Landscape of Pediatric Ewing Sarcoma

  Cancer Discovery · 2014 · https://doi.org/10.1158/2159-8290.cd-13-1037

• Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.2925

• Mutational heterogeneity in cancer and the search for new cancer-associated genes

  Nature · 2013 · https://doi.org/10.1038/nature12213

• Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

  The Lancet Oncology · 2013 · https://doi.org/10.1016/s1470-2045(13)70449-2

• A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers

  Journal of Clinical Investigation · 2012 · https://doi.org/10.1172/jci64400

• A DNA methylation fingerprint of 1628 human samples

  Genome Research · 2011 · https://doi.org/10.1101/gr.119867.110

• High TGFβ-Smad Activity Confers Poor Prognosis in Glioma Patients and Promotes Cell Proliferation Depending on the Methylation of the PDGF-B Gene

  Cancer Cell · 2007 · https://doi.org/10.1016/j.ccr.2006.11.023

• Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

  Nature · 2001 · https://doi.org/10.1038/35051606

Current projects

No projects listed.