Toshifumi Hibi∥

Research interests

Publications

• Filgotinib as induction and maintenance therapy for ulcerative colitis (SELECTION): a phase 2b/3 double-blind, randomised, placebo-controlled trial

  The Lancet · 2021 · https://doi.org/10.1016/s0140-6736(21)00666-8

• Ulcerative colitis

  Nature Reviews Disease Primers · 2020 · https://doi.org/10.1038/s41572-020-0205-x

• Somatic inflammatory gene mutations in human ulcerative colitis epithelium

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1844-5

• Evidence-based clinical practice guidelines for inflammatory bowel disease

  Journal of Gastroenterology · 2018 · https://doi.org/10.1007/s00535-018-1439-1

• Th17 plasticity and its relevance to inflammatory bowel disease

  Journal of Autoimmunity · 2017 · 10.1016/j.jaut.2017.12.004

• Adalimumab Monotherapy and a Combination with Azathioprine for Crohn’s Disease: A Prospective, Randomized Trial

  Journal of Crohn s and Colitis · 2016 · 10.1093/ecco-jcc/jjw152

• Subcutaneous Golimumab Induces Clinical Response and Remission in Patients With Moderate-to-Severe Ulcerative Colitis

  Gastroenterology · 2013 · https://doi.org/10.1053/j.gastro.2013.05.048

• Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

  Hepatology · 2013 · 10.1002/hep.26604

• A Single Strain of Clostridium butyricum Induces Intestinal IL-10-Producing Macrophages to Suppress Acute Experimental Colitis in Mice

  Cell Host & Microbe · 2013 · 10.1016/j.chom.2013.05.013

• Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011

  Modern Rheumatology · 2012 · https://doi.org/10.3109/s10165-011-0571-z

• Reactive Oxygen Species-Induced Autophagic Degradation of Helicobacter pylori CagA Is Specifically Suppressed in Cancer Stem-like Cells

  Cell Host & Microbe · 2012 · 10.1016/j.chom.2012.10.014

• Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011

  Modern Rheumatology · 2012 · https://doi.org/10.1007/s10165-011-0571-z

• A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells

  Gastroenterology · 2011 · 10.1053/j.gastro.2011.09.049

• Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health

  Gut · 2011 · 10.1136/gutjnl-2011-300049

• Imbalance of NKp44+NKp46− and NKp44−NKp46+ Natural Killer Cells in the Intestinal Mucosa of Patients With Crohn's Disease

  Gastroenterology · 2010 · 10.1053/j.gastro.2010.05.040

• Development of the Crohnʼs disease digestive damage score, the Lémann score

  Inflammatory Bowel Diseases · 2010 · 10.1002/ibd.21506

• Prevalence of ulcerative colitis and Crohn’s disease in Japan

  Journal of Gastroenterology · 2009 · 10.1007/s00535-009-0057-3

• IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn’s disease

  Gut · 2008 · 10.1136/gut.2007.135053

• Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis

  Journal of Clinical Investigation · 2008 · 10.1172/jci34610

• Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion

  Pharmacology & Therapeutics · 2007 · 10.1016/j.pharmthera.2007.09.008

• Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease

  International Journal of Medical Microbiology · 2007 · 10.1016/j.ijmm.2007.07.016

• A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn’s disease☆

  Gastroenterology · 2004 · 10.1053/j.gastro.2004.01.012

• Lack of common NOD2 variants in Japanese patients with Crohn's disease

  Gastroenterology · 2002 · 10.1053/gast.2002.34155

• Damaged epithelia regenerated by bone marrow–derived cells in the human gastrointestinal tract

  Nature Medicine · 2002 · https://doi.org/10.1038/nm755

• Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.

  Journal of Clinical Investigation · 1995 · 10.1172/jci118002

Current projects

No projects listed.