Hiroshi Tanaka

Research interests

Publications

• Datopotamab Deruxtecan Versus Docetaxel for Previously Treated Advanced or Metastatic Non–Small Cell Lung Cancer: The Randomized, Open-Label Phase III TROPION-Lung01 Study

  Journal of Clinical Oncology · 2024 · https://doi.org/10.1200/jco-24-01544

• Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled, phase 3 trial

  The Lancet Oncology · 2019 · https://doi.org/10.1016/s1470-2045(19)30634-5

• Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

  Science · 2015 · https://doi.org/10.1126/science.1259418

• Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

  Nature Communications · 2012 · https://doi.org/10.1038/ncomms1892

• AlzPathway: a comprehensive map of signaling pathways of Alzheimer’s disease

  BMC Systems Biology · 2012 · https://doi.org/10.1186/1752-0509-6-52

• Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer

  Gut · 2011 · https://doi.org/10.1136/gutjnl-2011-300050

• Clinical responses to EGFR-tyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: a retrospective analysis

  BMC Cancer · 2011 · https://doi.org/10.1186/1471-2407-11-1

• Clinical Significance of Osteoprotegerin Expression in Human Colorectal Cancer

  Clinical Cancer Research · 2011 · https://doi.org/10.1158/1078-0432.ccr-10-2884

• Diagnostic performance of diffusion-weighted magnetic resonance imaging in bladder cancer: potential utility of apparent diffusion coefficient values as a biomarker to predict clinical aggressiveness

  European Radiology · 2011 · https://doi.org/10.1007/s00330-011-2174-7

• Effect of maternal age on mitochondrial DNA copy number, ATP content and IVF outcome of bovine oocytes

  Reproduction Fertility and Development · 2011 · https://doi.org/10.1071/rd10133

• Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance

  Nature Medicine · 2010 · https://doi.org/10.1038/nm.2236

• Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

  Cancer Research · 2008 · https://doi.org/10.1158/0008-5472.can-07-5003

• Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients

  Blood · 2007 · https://doi.org/10.1182/blood-2007-06-094201

• Early infection of scutellum tissue with Agrobacterium allows high‐speed transformation of rice

  The Plant Journal · 2006 · https://doi.org/10.1111/j.1365-313x.2006.02836.x

• Erect leaves caused by brassinosteroid deficiency increase biomass production and grain yield in rice

  Nature Biotechnology · 2005 · https://doi.org/10.1038/nbt1173

• Function, Intracellular Localization and the Importance in Salt Tolerance of a Vacuolar Na+/H+ Antiporter from Rice

  Plant and Cell Physiology · 2004 · https://doi.org/10.1093/pcp/pch014

• Chondrogenic differentiation of murine embryonic stem cells: Effects of culture conditions and dexamethasone

  Journal of Cellular Biochemistry · 2004 · https://doi.org/10.1002/jcb.20171

• Controlled, prospective trial of steroid treatment in IgA nephropathy: a limitation of low-dose prednisolone therapy

  American Journal of Kidney Diseases · 2003 · https://doi.org/10.1016/s0272-6386(03)00194-x

• Depletion of CD4+CD25+ Regulatory Cells Augments the Generation of Specific Immune T Cells in Tumor-Draining Lymph Nodes

  Journal of Immunotherapy · 2002 · https://doi.org/10.1097/00002371-200205000-00003

• Steroid responsiveness and frequency of relapse in adult-onset minimal change nephrotic syndrome

  American Journal of Kidney Diseases · 2002 · https://doi.org/10.1053/ajkd.2002.31400

• Overtime work, insufficient sleep, and risk of non-fatal acute myocardial infarction in Japanese men

  Occupational and Environmental Medicine · 2002 · https://doi.org/10.1136/oem.59.7.447

• Expression of a Gibberellin 2-Oxidase Gene around the Shoot Apex Is Related to Phase Transition in Rice

  PLANT PHYSIOLOGY · 2001 · https://doi.org/10.1104/pp.125.3.1508

• Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT

  Nature Genetics · 1996 · https://doi.org/10.1038/ng1196-277

• The gene for Machado–Joseph disease maps to human chromosome 14q

  Nature Genetics · 1993 · https://doi.org/10.1038/ng0793-300

• Inherited Complete Deficiency of 20-Kilodalton Homologous Restriction Factor (CD59) as a Cause of Paroxysmal Nocturnal Hemoglobinuria

  New England Journal of Medicine · 1990 · https://doi.org/10.1056/nejm199010253231707

• On the growing up problem for semilinear heat equations

  Journal of the Mathematical Society of Japan · 1977 · https://doi.org/10.2969/jmsj/02930407

Current projects

No projects listed.