Hideo Baba

Research interests

Publications

• Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

  Nature Medicine · 2018 · https://doi.org/10.1038/s41591-018-0022-x

• Randomized clinical trial of adjuvant gemcitabine chemotherapy versus observation in resected bile duct cancer

  British journal of surgery · 2018 · https://doi.org/10.1002/bjs.10776

• Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial

  The Lancet · 2018 · https://doi.org/10.1016/s0140-6736(18)31257-1

• CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation – A target for novel cancer therapy

  Cancer Treatment Reviews · 2017 · https://doi.org/10.1016/j.ctrv.2017.11.007

• Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells

  Gastroenterology · 2017 · https://doi.org/10.1053/j.gastro.2017.03.046

• Fusobacterium nucleatum in Colorectal Carcinoma Tissue According to Tumor Location

  Clinical and Translational Gastroenterology · 2016 · https://doi.org/10.1038/ctg.2016.53

• Prognostic Nutritional Index Predicts Severe Complications, Recurrence, and Poor Prognosis in Patients With Colorectal Cancer Undergoing Primary Tumor Resection

  Diseases of the Colon & Rectum · 2015 · https://doi.org/10.1097/dcr.0000000000000458

• Long‐term and perioperative outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma with propensity score matching: a multi‐institutional Japanese study

  Journal of Hepato-Biliary-Pancreatic Sciences · 2015 · https://doi.org/10.1002/jhbp.276

• Leucovorin, fluorouracil, and oxaliplatin plus bevacizumab versus S-1 and oxaliplatin plus bevacizumab in patients with metastatic colorectal cancer (SOFT): an open-label, non-inferiority, randomised phase 3 trial

  The Lancet Oncology · 2013 · https://doi.org/10.1016/s1470-2045(13)70490-x

• Sarcopenia is a prognostic factor in living donor liver transplantation

  Liver Transplantation · 2013 · https://doi.org/10.1002/lt.23811

• Randomized Phase III Study of Gemcitabine Plus S-1, S-1 Alone, or Gemcitabine Alone in Patients With Locally Advanced and Metastatic Pancreatic Cancer in Japan and Taiwan: GEST Study

  Journal of Clinical Oncology · 2013 · https://doi.org/10.1200/jco.2012.43.3680

• Clinical impact of serum exosomal microRNA‐21 as a clinical biomarker in human esophageal squamous cell carcinoma

  Cancer · 2012 · https://doi.org/10.1002/cncr.27895

• A nomogram predicting disease‐free survival in patients with colorectal liver metastases treated with hepatic resection: multicenter data collection as a Project Study for Hepatic Surgery of the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery

  Journal of Hepato-Biliary-Pancreatic Sciences · 2011 · https://doi.org/10.1007/s00534-011-0460-z

• CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

  Cancer Cell · 2011 · https://doi.org/10.1016/j.ccr.2011.01.038

• Irinotecan plus S-1 (IRIS) versus fluorouracil and folinic acid plus irinotecan (FOLFIRI) as second-line chemotherapy for metastatic colorectal cancer: a randomised phase 2/3 non-inferiority study (FIRIS study)

  The Lancet Oncology · 2010 · https://doi.org/10.1016/s1470-2045(10)70181-9

• Activation of PI3K/Akt signaling and hormone resistance in breast cancer

  Breast Cancer · 2006 · https://doi.org/10.2325/jbcs.13.137

• Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients

  International Journal of Cancer · 2005 · https://doi.org/10.1002/ijc.21358

• Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer

  International Journal of Cancer · 2005 · https://doi.org/10.1002/ijc.21170

Current projects

No projects listed.