Hiroshi Sugiyama

Research interests

Publications

• Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease

  Nature Genetics · 2019 · 10.1038/s41588-019-0459-y

• Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy

  Molecules · 2019 · 10.3390/molecules24030429

• SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions

  Neuropathology · 2017 · 10.1111/neup.12373

• A light-driven three-dimensional plasmonic nanosystem that translates molecular motion into reversible chiroptical function

  Nature Communications · 2016 · 10.1038/ncomms10591

• Clinicopathological features of adult-onset neuronal intranuclear inclusion disease

  Brain · 2016 · 10.1093/brain/aww249

• RNA-DNA Triplex Formation by Long Noncoding RNAs

  Cell chemical biology · 2016 · 10.1016/j.chembiol.2016.09.011

• Lipid-bilayer-assisted two-dimensional self-assembly of DNA origami nanostructures

  Nature Communications · 2015 · 10.1038/ncomms9052

• A DNA-based molecular motor that can navigate a network of tracks

  Nature Nanotechnology · 2012 · 10.1038/nnano.2011.253

• Single‐Molecule Analysis Using DNA Origami

  Angewandte Chemie International Edition · 2011 · 10.1002/anie.201102113

• Direct observation of stepwise movement of a synthetic molecular transporter

  Nature Nanotechnology · 2011 · 10.1038/nnano.2010.284

• Photo-Cross-Linking-Assisted Thermal Stability of DNA Origami Structures and Its Application for Higher-Temperature Self-Assembly

  Journal of the American Chemical Society · 2011 · 10.1021/ja204546h

• A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands

  Nature Chemistry · 2011 · 10.1038/nchem.1126

• Programmed Two-Dimensional Self-Assembly of Multiple DNA Origami Jigsaw Pieces

  ACS Nano · 2010 · 10.1021/nn1031627

• Regulation of DNA Methylation Using Different Tensions of Double Strands Constructed in a Defined DNA Nanostructure

  Journal of the American Chemical Society · 2010 · 10.1021/ja907649w

• A Chiral Wedge Molecule Inhibits Telomerase Activity

  Journal of the American Chemical Society · 2010 · 10.1021/ja908897j

• Visualization of Dynamic Conformational Switching of the G-Quadruplex in a DNA Nanostructure

  Journal of the American Chemical Society · 2010 · 10.1021/ja1058907

• Synthesis and Biological Properties of Sequence-Specific DNA-Alkylating Pyrrole−Imidazole Polyamides

  Accounts of Chemical Research · 2006 · 10.1021/ar030287f

• The new models of the human telomere d[AGGG(TTAGGG)3] in K+ solution

  Bioorganic & Medicinal Chemistry · 2006 · 10.1016/j.bmc.2006.04.033

• (P)-Helicene Displays Chiral Selection in Binding to Z-DNA

  Journal of the American Chemical Society · 2004 · 10.1021/ja0499748

• Possible cause of G·C→C·G transversion mutation by guanine oxidation product, imidazolone

  Chemistry & Biology · 2001 · 10.1016/s1074-5521(01)00019-9

• Product Analysis of GG-Specific Photooxidation of DNA via Electron Transfer: 2-Aminoimidazolone as a Major Guanine Oxidation Product

  Journal of the American Chemical Society · 1998 · 10.1021/ja980763a

• Mapping of the Hot Spots for DNA Damage by One-Electron Oxidation: Efficacy of GG Doublets and GGG Triplets as a Trap in Long-Range Hole Migration

  Journal of the American Chemical Society · 1998 · https://doi.org/10.1021/ja981888i

• Theoretical Studies of GG-Specific Photocleavage of DNA via Electron Transfer: Significant Lowering of Ionization Potential and 5‘-Localization of HOMO of Stacked GG Bases in B-Form DNA

  Journal of the American Chemical Society · 1996 · 10.1021/ja9609821

• Photoinduced DNA Cleavage via Electron Transfer: Demonstration That Guanine Residues Located 5' to Guanine Are the Most Electron-Donating Sites

  Journal of the American Chemical Society · 1995 · 10.1021/ja00128a050

• 13C nuclear magnetic resonance spectra of glucobioses, glucotrioses, and glucans

  Journal of the Chemical Society Perkin Transactions 1 · 1973 · 10.1039/p19730002425

Current projects

No projects listed.