Ryōsuke Takahashi

Research interests

Publications

• Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

  Molecular Neurodegeneration · 2018 · https://doi.org/10.1186/s13024-018-0257-5

• Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

  Nature · 2017 · https://doi.org/10.1038/nature23664

• The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis

  Science Translational Medicine · 2017 · https://doi.org/10.1126/scitranslmed.aaf3962

• Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

  Cell stem cell · 2013 · https://doi.org/10.1016/j.stem.2013.01.009

• Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

  PLoS Genetics · 2012 · https://doi.org/10.1371/journal.pgen.1002537

• Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells

  Proceedings of the National Academy of Sciences · 2012 · https://doi.org/10.1073/pnas.1209979109

• Motor Neuron-specific Disruption of Proteasomes, but Not Autophagy, Replicates Amyotrophic Lateral Sclerosis

  Journal of Biological Chemistry · 2012 · https://doi.org/10.1074/jbc.m112.417600

• Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

  Science Translational Medicine · 2012 · https://doi.org/10.1126/scitranslmed.3004052

• P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating

  PLoS ONE · 2011 · https://doi.org/10.1371/journal.pone.0021050

• Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts

  Acta Neuropathologica · 2011 · https://doi.org/10.1007/s00401-011-0925-9

• A rotarod test for evaluation of motor skill learning

  Journal of Neuroscience Methods · 2010 · https://doi.org/10.1016/j.jneumeth.2010.03.026

• Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

  Nature Neuroscience · 2008 · https://doi.org/10.1038/nn2047

• Phosphorylation of 4E‐BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

  The EMBO Journal · 2008 · https://doi.org/10.1038/emboj.2008.163

• Selective Impairment of Working Memory in a Mouse Model of Chronic Cerebral Hypoperfusion

  Stroke · 2007 · https://doi.org/10.1161/strokeaha.107.490151

• Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

  Proceedings of the National Academy of Sciences · 2005 · https://doi.org/10.1073/pnas.0504610102

• Parkin Suppresses Dopaminergic Neuron-Selective Neurotoxicity Induced by Pael-R in Drosophila

  Neuron · 2003 · https://doi.org/10.1016/s0896-6273(03)00143-0

• Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

  Biochemical and Biophysical Research Communications · 2003 · https://doi.org/10.1016/j.bbrc.2003.11.056

• Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis

  Journal of Neurochemistry · 2002 · https://doi.org/10.1046/j.1471-4159.2002.01211.x

• CHIP Is Associated with Parkin, a Gene Responsible for Familial Parkinson's Disease, and Enhances Its Ubiquitin Ligase Activity

  Molecular Cell · 2002 · https://doi.org/10.1016/s1097-2765(02)00583-x

• A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death

  Molecular Cell · 2001 · https://doi.org/10.1016/s1097-2765(01)00341-0

• Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

  Proceedings of the National Academy of Sciences · 2001 · https://doi.org/10.1073/pnas.161506698

• X-linked Inhibitor of Apoptosis Protein (XIAP) Inhibits Caspase-3 and -7 in Distinct Modes

  Journal of Biological Chemistry · 2001 · https://doi.org/10.1074/jbc.m102415200

• An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin

  Cell · 2001 · https://doi.org/10.1016/s0092-8674(01)00407-x

• Parkin Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity

  Journal of Biological Chemistry · 2000 · https://doi.org/10.1074/jbc.c000447200

• A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases

  Journal of Biological Chemistry · 1998 · https://doi.org/10.1074/jbc.273.14.7787

• X-linked IAP is a direct inhibitor of cell-death proteases

  Nature · 1997 · https://doi.org/10.1038/40901

Current projects

No projects listed.