Tsutomu Chiba

Research interests

Publications

• Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1856-1

• Risk of Cancer in Patients With Autoimmune Pancreatitis

  The American Journal of Gastroenterology · 2013 · https://doi.org/10.1038/ajg.2012.465

• Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011

  Modern Rheumatology · 2012 · https://doi.org/10.1007/s10165-011-0571-z

• Dclk1 distinguishes between tumor and normal stem cells in the intestine

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2481

• Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011

  Modern Rheumatology · 2012 · https://doi.org/10.3109/s10165-011-0571-z

• Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

  The Journal of Experimental Medicine · 2012 · https://doi.org/10.1084/jem.200509402092c

• Inflammation-Associated Cancer Development in Digestive Organs: Mechanisms and Roles for Genetic and Epigenetic Modulation

  Gastroenterology · 2012 · https://doi.org/10.1053/j.gastro.2012.07.009

• Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers

  Cancer Chemotherapy and Pharmacology · 2011 · https://doi.org/10.1007/s00280-011-1673-1

• NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

  Journal of Clinical Investigation · 2010 · https://doi.org/10.1172/jci39481

• A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer

  Cancer Chemotherapy and Pharmacology · 2010 · https://doi.org/10.1007/s00280-010-1470-2

• Second Asia–Pacific Consensus Guidelines for Helicobacter pylori infection

  Journal of Gastroenterology and Hepatology · 2009 · https://doi.org/10.1111/j.1440-1746.2009.05982.x

• Asia–Pacific consensus guidelines on gastric cancer prevention

  Journal of Gastroenterology and Hepatology · 2008 · https://doi.org/10.1111/j.1440-1746.2008.05314.x

• Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells

  Science · 2008 · https://doi.org/10.1126/science.1154884

• Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium

  Nature Medicine · 2007 · https://doi.org/10.1038/nm1566

• Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3 + CD25 + CD4 + regulatory T cells

  The Journal of Experimental Medicine · 2005 · https://doi.org/10.1084/jem.20050940

• Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture

  Development · 2005 · https://doi.org/10.1242/dev.02005

• Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells

  Nature Biotechnology · 2005 · https://doi.org/10.1038/nbt1167

• STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells

  Oncogene · 2004 · https://doi.org/10.1038/sj.onc.1207606

• Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut

  Proceedings of the National Academy of Sciences · 2004 · https://doi.org/10.1073/pnas.0307317101

• Candidate markers for stem and early progenitor cells, Musashi‐1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine

  FEBS Letters · 2003 · https://doi.org/10.1016/s0014-5793(02)03896-6

• Methyl-CpG Binding Domain 1 (MBD1) Interacts with the Suv39h1-HP1 Heterochromatic Complex for DNA Methylation-based Transcriptional Repression

  Journal of Biological Chemistry · 2003 · https://doi.org/10.1074/jbc.m302283200

• Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps.

  PubMed · 2002

• Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2-type cellular immune response

  Gastroenterology · 2000 · https://doi.org/10.1016/s0016-5085(00)70264-2

• Hepatitis C Virus Core Protein Inhibits Fas- and Tumor Necrosis Factor Alpha-Mediated Apoptosis via NF-κB Activation

  Journal of Virology · 1999 · https://doi.org/10.1128/jvi.73.6.4713-4720.1999

• TRANSMISSION OF HEPATITIS B VIRUS FROM HEPATITIS B CORE ANTIBODY-POSITIVE DONORS IN LIVING RELATED LIVER TRANSPLANTS

  Transplantation · 1998 · https://doi.org/10.1097/00007890-199802270-00007

Current projects

No projects listed.