Takanori Kanai∥

Research interests

Publications

• CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-021-24734-0

• An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.10.023

• The liver–brain–gut neural arc maintains the Treg cell niche in the gut

  Nature · 2020 · https://doi.org/10.1038/s41586-020-2425-3

• Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

  Nature Microbiology · 2019 · https://doi.org/10.1038/s41564-018-0333-1

• Somatic inflammatory gene mutations in human ulcerative colitis epithelium

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1844-5

• Evidence-based clinical practice guidelines for inflammatory bowel disease

  Journal of Gastroenterology · 2018 · https://doi.org/10.1007/s00535-018-1439-1

• Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

  Cell stem cell · 2018 · https://doi.org/10.1016/j.stem.2017.12.009

• Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.07.027

• The effect of fecal microbiota transplantation on psychiatric symptoms among patients with irritable bowel syndrome, functional diarrhea and functional constipation: An open-label observational study

  Journal of Affective Disorders · 2018 · https://doi.org/10.1016/j.jad.2018.04.038

• Visualization and targeting of LGR5+ human colon cancer stem cells

  Nature · 2017 · https://doi.org/10.1038/nature22081

• Bifidobacterium-Rich Fecal Donor May Be a Positive Predictor for Successful Fecal Microbiota Transplantation in Patients with Irritable Bowel Syndrome

  Digestion · 2017 · https://doi.org/10.1159/000471919

• Adalimumab Monotherapy and a Combination with Azathioprine for Crohn’s Disease: A Prospective, Randomized Trial

  Journal of Crohn s and Colitis · 2016 · https://doi.org/10.1093/ecco-jcc/jjw152

• A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

  Cell stem cell · 2016 · https://doi.org/10.1016/j.stem.2016.04.003

• Inhibition of Dectin-1 Signaling Ameliorates Colitis by Inducing Lactobacillus-Mediated Regulatory T Cell Expansion in the Intestine

  Cell Host & Microbe · 2015 · https://doi.org/10.1016/j.chom.2015.07.003

• Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

  Nature Medicine · 2015 · https://doi.org/10.1038/nm.3802

• The gut microbiota and inflammatory bowel disease

  Seminars in Immunopathology · 2014 · https://doi.org/10.1007/s00281-014-0454-4

• Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

  Hepatology · 2013 · https://doi.org/10.1002/hep.26604

• A Single Strain of Clostridium butyricum Induces Intestinal IL-10-Producing Macrophages to Suppress Acute Experimental Colitis in Mice

  Cell Host & Microbe · 2013 · https://doi.org/10.1016/j.chom.2013.05.013

• TGR 5 signalling inhibits the production of pro‐inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease

  Immunology · 2013 · https://doi.org/10.1111/imm.12045

• A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells

  Gastroenterology · 2011 · https://doi.org/10.1053/j.gastro.2011.09.049

• Imbalance of NKp44+NKp46− and NKp44−NKp46+ Natural Killer Cells in the Intestinal Mucosa of Patients With Crohn's Disease

  Gastroenterology · 2010 · https://doi.org/10.1053/j.gastro.2010.05.040

• MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis

  Journal of Gastroenterology · 2005 · https://doi.org/10.1007/s00535-004-1492-9

• CD4+CD25bright T Cells in Human Intestinal Lamina Propria as Regulatory Cells

  The Journal of Immunology · 2004 · https://doi.org/10.4049/jimmunol.173.5.3119

• Damaged epithelia regenerated by bone marrow–derived cells in the human gastrointestinal tract

  Nature Medicine · 2002 · https://doi.org/10.1038/nm755

• Macrophage-derived IL-18–mediated intestinal inflammation in the murine model of Crohn's disease

  Gastroenterology · 2001 · https://doi.org/10.1053/gast.2001.28021

Current projects

No projects listed.