Hiromi Rakugi

Research interests

Publications

• Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis

  The Lancet · 2021 · https://doi.org/10.1016/s0140-6736(21)00590-0

• Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis

  The Lancet · 2021 · https://doi.org/10.1016/s0140-6736(21)01921-8

• The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)

  Hypertension Research · 2019 · https://doi.org/10.1038/s41440-019-0284-9

• Source of Chronic Inflammation in Aging

  Frontiers in Cardiovascular Medicine · 2018 · 10.3389/fcvm.2018.00012

• Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017

  Journal of Atherosclerosis and Thrombosis · 2018 · https://doi.org/10.5551/jat.gl2017

• Redefining the elderly as aged 75 years and older: Proposal from the Joint Committee of Japan Gerontological Society and the Japan Geriatrics Society

  Geriatrics and gerontology international/Geriatrics & gerontology international · 2017 · 10.1111/ggi.13118

• Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice

  Scientific Reports · 2017 · 10.1038/srep42323

• Prevalence of frailty in Japan: A systematic review and meta-analysis

  Journal of Epidemiology · 2016 · 10.1016/j.je.2016.09.008

• J apan as the front‐runner of super‐aged societies: Perspectives from medicine and medical care in J apan

  Geriatrics and gerontology international/Geriatrics & gerontology international · 2015 · 10.1111/ggi.12450

• Erratum: The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009)

  Hypertension Research · 2014 · 10.1038/hr.2014.68

• Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma

  Endocrine Related Cancer · 2014 · 10.1530/erc-13-0494

• Hypomagnesemia is a significant predictor of cardiovascular and non-cardiovascular mortality in patients undergoing hemodialysis

  Kidney International · 2013 · 10.1038/ki.2013.327

• Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation

  Cell · 2013 · 10.1016/j.cell.2013.04.034

• ANRIL: Molecular Mechanisms and Implications in Human Health

  International Journal of Molecular Sciences · 2013 · 10.3390/ijms14011278

• Autophagy Guards Against Cisplatin-Induced Acute Kidney Injury

  American Journal Of Pathology · 2012 · 10.1016/j.ajpath.2011.11.001

• Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B

  Atherosclerosis · 2011 · 10.1016/j.atherosclerosis.2011.11.017

• Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury

  Journal of the American Society of Nephrology · 2011 · 10.1681/asn.2010070705

• Target Blood Pressure for Treatment of Isolated Systolic Hypertension in the Elderly

  Hypertension · 2010 · 10.1161/hypertensionaha.109.146035

• Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes

  Proceedings of the National Academy of Sciences · 2010 · 10.1073/pnas.1000645107

• Klotho suppresses TNF-α-induced expression of adhesion molecules in the endothelium and attenuates NF-κB activation

  Endocrine · 2009 · 10.1007/s12020-009-9181-3

• Erratum: The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009)—Chapter 2

  Hypertension Research · 2009 · 10.1038/hr.2009.34

• Deletion of Angiotensin-Converting Enzyme 2 Accelerates Pressure Overload-Induced Cardiac Dysfunction by Increasing Local Angiotensin II

  Hypertension · 2006 · 10.1161/01.hyp.0000205833.89478.5b

• Hypoadiponectinemia Is an Independent Risk Factor for Hypertension

  Hypertension · 2004 · 10.1161/01.hyp.0000129281.03801.4b

• Association of Hypoadiponectinemia With Impaired Vasoreactivity

  Hypertension · 2003 · 10.1161/01.hyp.0000083488.67550.b8

• Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives

  American Journal of Hypertension · 1995 · 10.1016/0895-7061(95)96214-5

Current projects

No projects listed.