Woong‐Yang Park

Research interests

Publications

• Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer

  Nature Genetics · 2022 · 10.1038/s41588-022-01100-4

• Determinants of Response and Intrinsic Resistance to PD-1 Blockade in Microsatellite Instability–High Gastric Cancer

  Cancer Discovery · 2021 · 10.1158/2159-8290.cd-21-0219

• Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer

  Nature Genetics · 2020 · 10.1038/s41588-020-0636-z

• Single-cell RNA sequencing reveals the tumor microenvironment and facilitates strategic choices to circumvent treatment failure in a chemorefractory bladder cancer patient

  Genome Medicine · 2020 · 10.1186/s13073-020-00741-6

• Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-16164-1

• Concurrent Genetic Alterations Predict the Progression to Target Therapy in EGFR-Mutated Advanced NSCLC

  Journal of Thoracic Oncology · 2018 · 10.1016/j.jtho.2018.10.150

• Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy

  Nature Genetics · 2018 · 10.1038/s41588-018-0209-6

• Multi-omics profiling of younger Asian breast cancers reveals distinctive molecular signatures

  Nature Communications · 2018 · 10.1038/s41467-018-04129-4

• Linking transcriptional and genetic tumor heterogeneity through allele analysis of single-cell RNA-seq data

  Genome Research · 2018 · https://doi.org/10.1101/gr.228080.117

• Spatiotemporal genomic architecture informs precision oncology in glioblastoma

  Nature Genetics · 2017 · 10.1038/ng.3806

• Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer

  Nature Communications · 2017 · 10.1038/ncomms15081

• A molecular portrait of microsatellite instability across multiple cancers

  Nature Communications · 2017 · 10.1038/ncomms15180

• Prevalence and detection of low-allele-fraction variants in clinical cancer samples

  Nature Communications · 2017 · 10.1038/s41467-017-01470-y

• Clonal evolution of glioblastoma under therapy

  Nature Genetics · 2016 · 10.1038/ng.3590

• Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma

  Genome biology · 2016 · 10.1186/s13059-016-0945-9

• Intron retention is a widespread mechanism of tumor-suppressor inactivation

  Nature Genetics · 2015 · 10.1038/ng.3414

• Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells

  Genome biology · 2015 · 10.1186/s13059-015-0692-3

• Spatiotemporal Evolution of the Primary Glioblastoma Genome

  Cancer Cell · 2015 · 10.1016/j.ccell.2015.07.013

• The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma

  Cancer Cell · 2014 · https://doi.org/10.1016/j.ccr.2014.07.014

• Patient-Specific Orthotopic Glioblastoma Xenograft Models Recapitulate the Histopathology and Biology of Human Glioblastomas In Situ

  Cell Reports · 2013 · 10.1016/j.celrep.2012.12.013

• Neuronal Elav-like (Hu) Proteins Regulate RNA Splicing and Abundance to Control Glutamate Levels and Neuronal Excitability

  Neuron · 2012 · 10.1016/j.neuron.2012.07.009

• A Single Recurrent Mutation in the 5′-UTR of IFITM5 Causes Osteogenesis Imperfecta Type V

  The American Journal of Human Genetics · 2012 · 10.1016/j.ajhg.2012.06.005

• A highly annotated whole-genome sequence of a Korean individual

  Nature · 2009 · https://doi.org/10.1038/nature08211

• Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas

  Laboratory Investigation · 2008 · 10.1038/labinvest.2008.57

• Up-regulation of Caveolin Attenuates Epidermal Growth Factor Signaling in Senescent Cells

  Journal of Biological Chemistry · 2000 · 10.1074/jbc.m908162199

Current projects

No projects listed.