David M. Wilson

Research interests

Publications

• EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

  Cell chemical biology · 2019 · 10.1016/j.chembiol.2019.11.004

• EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

  Cell chemical biology · 2019 · 10.1016/j.chembiol.2019.11.004

• Organic synthesis provides opportunities to transform drug discovery

  Nature Chemistry · 2018 · https://doi.org/10.1038/s41557-018-0021-z

• Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6

  ACS Chemical Biology · 2018 · 10.1021/acschembio.8b00698

• Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-07551-w

• Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

  PLoS Medicine · 2017 · 10.1371/journal.pmed.1002258

• Potent and selective bivalent inhibitors of BET bromodomains

  Nature Chemical Biology · 2016 · 10.1038/nchembio.2210

• Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease

  JAMA Neurology · 2016 · 10.1001/jamaneurol.2016.0150

• Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

  Nature Chemical Biology · 2015 · https://doi.org/10.1038/nchembio.1735

• A Boronate-Caged [18F]FLT Probe for Hydrogen Peroxide Detection Using Positron Emission Tomography

  Journal of the American Chemical Society · 2014 · 10.1021/ja509198w

• Chemistry and biochemistry of 13 C hyperpolarized magnetic resonance using dynamic nuclear polarization

  Chemical Society Reviews · 2013 · 10.1039/c3cs60124b

• Olympic boxing is associated with elevated levels of the neuronal protein tau in plasma

  Brain Injury · 2013 · 10.3109/02699052.2012.750752

• Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)

  Bioorganic & Medicinal Chemistry Letters · 2012 · 10.1016/j.bmcl.2012.02.041

• A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

  Nature · 2012 · https://doi.org/10.1038/nature11262

• Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)

  Bioorganic & Medicinal Chemistry Letters · 2012 · 10.1016/j.bmcl.2012.02.041

• Hyperpolarized 13 C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging

  Proceedings of the National Academy of Sciences · 2011 · 10.1073/pnas.1106920108

• Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides

  Journal of Medicinal Chemistry · 2011 · 10.1021/jm201283q

• Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo

  Journal of Magnetic Resonance · 2010 · 10.1016/j.jmr.2010.04.012

• The first WASP public data release

  Astronomy and Astrophysics · 2010 · 10.1051/0004-6361/201015655

• An orbital period of 0.94 days for the hot-Jupiter planet WASP-18b

  Nature · 2009 · https://doi.org/10.1038/nature08245

• WASP-17b: AN ULTRA-LOW DENSITY PLANET IN A PROBABLE RETROGRADE ORBIT

  The Astrophysical Journal · 2009 · https://doi.org/10.1088/0004-637x/709/1/159

• WASP-12b: THE HOTTEST TRANSITING EXTRASOLAR PLANET YET DISCOVERED

  The Astrophysical Journal · 2009 · 10.1088/0004-637x/693/2/1920

• Improved parameters for the transiting hot Jupiters WASP-4b and WASP-5b

  Astronomy and Astrophysics · 2009 · 10.1051/0004-6361:200810929

• WASP-4b: A 12th Magnitude Transiting Hot Jupiter in the Southern Hemisphere

  The Astrophysical Journal · 2008 · 10.1086/586735

• Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral, Small-Molecule Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) in Patients With Advanced Cancers

  Journal of Clinical Oncology · 2008 · https://doi.org/10.1200/jco.2007.14.4956

• Efficient identification of exoplanetary transit candidates from SuperWASP light curves

  Monthly Notices of the Royal Astronomical Society · 2007 · 10.1111/j.1365-2966.2007.12195.x

• WASP-1b and WASP-2b: two new transiting exoplanets detected with SuperWASP and SOPHIE

  Monthly Notices of the Royal Astronomical Society · 2007 · 10.1111/j.1365-2966.2006.11350.x

• GSK189254, a Novel H3 Receptor Antagonist That Binds to Histamine H3 Receptors in Alzheimer’s Disease Brain and Improves Cognitive Performance in Preclinical Models

  Journal of Pharmacology and Experimental Therapeutics · 2007 · 10.1124/jpet.107.120311

• Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic BRAF by the Kinase Inhibitor SB-590885

  Cancer Research · 2006 · 10.1158/0008-5472.can-06-2554

• The identification of potent and selective imidazole-based inhibitors of B-Raf kinase

  Bioorganic & Medicinal Chemistry Letters · 2005 · 10.1016/j.bmcl.2005.09.072

• The identification of potent and selective imidazole-based inhibitors of B-Raf kinase

  Bioorganic & Medicinal Chemistry Letters · 2005 · 10.1016/j.bmcl.2005.09.072

• Cyclodextrin Dimers as Cleavable Carriers of Photodynamic Sensitizers

  Journal of the American Chemical Society · 2001 · 10.1021/ja011709o

• Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease.

  PubMed · 1997

• Palladium catalysed tandem cyclisation-anion capture processes. Part 3. Organoboron anion transfer agents

  Tetrahedron · 1997 · 10.1016/s0040-4020(97)00754-0

Current projects

No projects listed.