Yung Seng Lee

Research interests

Publications

• Engineered commensals for targeted nose-to-brain drug delivery

  Cell · 2025 · https://doi.org/10.1016/j.cell.2025.01.017

• Engineering probiotics to inhibit Clostridioides difficile infection by dynamic regulation of intestinal metabolism

  Nature Communications · 2022 · https://doi.org/10.1038/s41467-022-31334-z

• Cohort profile: Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO)

  European Journal of Epidemiology · 2020 · https://doi.org/10.1007/s10654-020-00697-2

• Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention

  Nature Biomedical Engineering · 2018 · https://doi.org/10.1038/s41551-017-0181-y

• Faster eating rates are associated with higher energy intakes during an ad libitum meal, higher BMI and greater adiposity among 4·5-year-old children: results from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort

  British Journal Of Nutrition · 2017 · https://doi.org/10.1017/s0007114517000848

• Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome

  BMC Medicine · 2017 · https://doi.org/10.1186/s12916-017-0800-1

• Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models

  Nature Communications · 2017 · https://doi.org/10.1038/ncomms15028

• Microbiome engineering: Current applications and its future

  Biotechnology Journal · 2017 · https://doi.org/10.1002/biot.201600099

• High folate and low vitamin B12 status during pregnancy is associated with gestational diabetes mellitus

  Clinical Nutrition · 2017 · https://doi.org/10.1016/j.clnu.2017.03.022

• Singaporean Mothers’ Perception of Their Three-year-old Child’s Weight Status: A Cross-Sectional Study

  PLoS ONE · 2016 · https://doi.org/10.1371/journal.pone.0147563

• Dynamics of Infant Gut Microbiota Are Influenced by Delivery Mode and Gestational Duration and Are Associated with Subsequent Adiposity

  mBio · 2015 · https://doi.org/10.1128/mbio.02419-14

• Rate of establishing the gut microbiota in infancy has consequences for future health

  Gut Microbes · 2015 · https://doi.org/10.1080/19490976.2015.1078051

• Relationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study

  Journal of Psychiatric Research · 2014 · https://doi.org/10.1016/j.jpsychires.2014.04.006

• Cohort Profile: Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study

  International Journal of Epidemiology · 2013 · https://doi.org/10.1093/ije/dyt125

• The Relationship between Growth Spurts and Myopia in Singapore Children

  Investigative Ophthalmology & Visual Science · 2012 · https://doi.org/10.1167/iovs.12-10402

• Overexpression of stathmin1 in the diffuse type of gastric cancer and its roles in proliferation and migration of gastric cancer cells

  British Journal of Cancer · 2010 · https://doi.org/10.1038/sj.bjc.6605537

• Ultrasound Imaging of the Lumbar Spine in the Transverse Plane: The Correlation Between Estimated and Actual Depth to the Epidural Space in Obese Parturients

  Anesthesia & Analgesia · 2009 · https://doi.org/10.1213/ane.0b013e3181a323f6

• Consequences of Childhood Obesity

  Annals of the Academy of Medicine Singapore · 2009 · https://doi.org/10.47102/annals-acadmedsg.v38n1p75

• Phenotypic variability in 17β‐hydroxysteroid dehydrogenase‐3 deficiency and diagnostic pitfalls

  Clinical Endocrinology · 2007 · https://doi.org/10.1111/j.1365-2265.2007.02829.x

• The Role of Melanocortin 3 Receptor Gene in Childhood Obesity

  Diabetes · 2007 · https://doi.org/10.2337/db07-0225

• A POMC variant implicates β-melanocyte-stimulating hormone in the control of human energy balance

  Cell Metabolism · 2006 · https://doi.org/10.1016/j.cmet.2006.01.006

• Correlation between genotype, phenotype and sex of rearing in 111 patients with partial androgen insensitivity syndrome

  Clinical Endocrinology · 2005 · https://doi.org/10.1111/j.1365-2265.2005.02298.x

• Clinical effect of imatinib added to intensive combination chemotherapy for newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia

  Leukemia · 2005 · https://doi.org/10.1038/sj.leu.2403886

• Treatment of relapsed acute myeloid leukemia after allogeneic bone marrow transplantation with chemotherapy followed by G-CSF-primed donor leukocyte infusion: a high incidence of isolated extramedullary relapse

  Leukemia · 2004 · https://doi.org/10.1038/sj.leu.2403523

• Bone marrow vs extramedullary relapse of acute leukemia after allogeneic hematopoietic cell transplantation: risk factors and clinical course

  Bone Marrow Transplantation · 2003 · https://doi.org/10.1038/sj.bmt.1704223

• A Novel Melanocortin 3 Receptor Gene (MC3R) Mutation Associated with Severe Obesity

  The Journal of Clinical Endocrinology & Metabolism · 2002 · https://doi.org/10.1210/jcem.87.3.8461

• Modelling and Vibration Analysis of Misaligned Rotor-Ball Bearing Systems

  Journal of Sound and Vibration · 1999 · https://doi.org/10.1006/jsvi.1997.1301

Current projects

No projects listed.