Robert W. Wilkinson

Research interests

Publications

• Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1+ Activated T Cells

  Cancer Discovery · 2021 · 10.1158/2159-8290.cd-20-1445

• Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment

  Clinical Cancer Research · 2020 · 10.1158/1078-0432.ccr-20-0472

• Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies

  Journal for ImmunoTherapy of Cancer · 2019 · https://doi.org/10.1186/s40425-019-0724-8

• CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype

  Cell Reports · 2018 · 10.1016/j.celrep.2018.03.131

• Fractionated Radiation Therapy Stimulates Antitumor Immunity Mediated by Both Resident and Infiltrating Polyclonal T-cell Populations when Combined with PD-1 Blockade

  Clinical Cancer Research · 2017 · https://doi.org/10.1158/1078-0432.ccr-16-1673

• Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery

  Cancer Immunology Research · 2016 · https://doi.org/10.1158/2326-6066.cir-16-0114

• Identification and Characterization of MEDI4736, an Antagonistic Anti–PD-L1 Monoclonal Antibody

  Cancer Immunology Research · 2015 · https://doi.org/10.1158/2326-6066.cir-14-0191

• Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade

  Cancer Research · 2014 · https://doi.org/10.1158/0008-5472.can-14-1258

• Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

  Molecular Oncology · 2009 · 10.1016/j.molonc.2009.01.002

• AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis

  Clinical Cancer Research · 2007 · 10.1158/1078-0432.ccr-06-2979

• Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase

  Journal of Medicinal Chemistry · 2007 · 10.1021/jm061335f

• Correction of acidosis in humans with CRF decreases protein degradation and amino acid oxidation

  American Journal of Physiology-Endocrinology and Metabolism · 1993 · 10.1152/ajpendo.1993.265.2.e230

• OUTCOME IN PATIENTS ON CONTINUOUS AMBULATORY PERITONEAL DIALYSIS AND HAEMODIALYSIS: 4-YEAR ANALYSIS OF A PROSPECTIVE MULTICENTRE STUDY

  The Lancet · 1987 · 10.1016/s0140-6736(87)91544-3

• EPIDEMIOLOGY OF ACROMEGALY IN THE NEWCASTLE REGION

  Clinical Endocrinology · 1980 · https://doi.org/10.1111/j.1365-2265.1980.tb03135.x

Current projects

No projects listed.