Simon T. Barry

Research interests

Publications

• Biomarker-directed targeted therapy plus durvalumab in advanced non-small-cell lung cancer: a phase 2 umbrella trial

  Nature Medicine · 2024 · 10.1038/s41591-024-02808-y

• Therapeutic targeting of tumour myeloid cells

  Nature reviews. Cancer · 2023 · https://doi.org/10.1038/s41568-022-00546-2

• CXCR2 inhibition enables NASH-HCC immunotherapy

  Gut · 2022 · 10.1136/gutjnl-2021-326259

• The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-020-00753-3

• HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

  Cell Reports · 2020 · 10.1016/j.celrep.2020.107625

• MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects

  Nature Immunology · 2020 · 10.1038/s41590-020-00818-9

• Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

  Gastroenterology · 2020 · 10.1053/j.gastro.2020.09.043

• Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer

  Cell Reports · 2019 · 10.1016/j.celrep.2019.07.068

• Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

  Cancer Cell · 2019 · https://doi.org/10.1016/j.ccell.2019.08.003

• Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival

  Cancer Discovery · 2018 · 10.1158/2159-8290.cd-18-0389

• TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

  Science Translational Medicine · 2018 · 10.1126/scitranslmed.aan1230

• CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype

  Cell Reports · 2018 · 10.1016/j.celrep.2018.03.131

• IL-23 secreted by myeloid cells drives castration-resistant prostate cancer

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0266-0

• Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo

  Science Translational Medicine · 2016 · 10.1126/scitranslmed.aad2355

• Challenges and strategies in anti-cancer nanomedicine development: An industry perspective

  Advanced Drug Delivery Reviews · 2016 · https://doi.org/10.1016/j.addr.2016.04.025

• CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.04.014

• WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited

  Journal of Clinical Investigation · 2015 · 10.1172/jci76452

• Therapeutic Targeting of Integrin αvβ6 in Breast Cancer

  JNCI Journal of the National Cancer Institute · 2014 · 10.1093/jnci/dju169

• Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

  Cancer Research · 2013 · https://doi.org/10.1158/0008-5472.can-12-4561

• Tumor Stromal Architecture Can Define the Intrinsic Tumor Response to VEGF-Targeted Therapy

  Clinical Cancer Research · 2013 · 10.1158/1078-0432.ccr-13-1637

• AZD2171: A Highly Potent, Orally Bioavailable, Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor for the Treatment of Cancer

  Cancer Research · 2005 · https://doi.org/10.1158/0008-5472.can-04-4409

• PDGF-regulated rab4-dependent recycling of αvβ3 integrin from early endosomes is necessary for cell adhesion and spreading

  Current Biology · 2001 · 10.1016/s0960-9822(01)00442-0

• ARF1 Mediates Paxillin Recruitment to Focal Adhesions and Potentiates Rho-stimulated Stress Fiber Formation in Intact and Permeabilized Swiss 3T3 Fibroblasts

  The Journal of Cell Biology · 1998 · 10.1083/jcb.143.7.1981

• Acidic phospholipids inhibit the intramolecular association between the N- and C-terminal regions of vinculin, exposing actin-binding and protein kinase C phosphorylation sites

  Biochemical Journal · 1996 · 10.1042/bj3140827

• The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-δ to focal adhesions

  Journal of Cell Science · 1994 · 10.1242/jcs.107.7.2033

Current projects

No projects listed.