Je Kyung Seong

Research interests

Publications

• Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity

  npj Precision Oncology · 2022 · https://doi.org/10.1038/s41698-022-00251-1

• Targeted mutagenesis in mouse cells and embryos using an enhanced prime editor

  Genome biology · 2021 · https://doi.org/10.1186/s13059-021-02389-w

• Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis

  Autophagy · 2019 · https://doi.org/10.1080/15548627.2019.1569931

• The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation

  Conservation Genetics · 2018 · https://doi.org/10.1007/s10592-018-1072-9

• Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

  Circulation Research · 2018 · https://doi.org/10.1161/circresaha.118.312804

• Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3901

• RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network

  Nature Communications · 2017 · https://doi.org/10.1038/s41467-017-00215-1

• PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models

  Cancer Research · 2017 · https://doi.org/10.1158/0008-5472.can-17-0582

• Sex differences in sympathetic innervation and browning of white adipose tissue of mice

  Biology of Sex Differences · 2016 · https://doi.org/10.1186/s13293-016-0121-7

• CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3

  Nature Cell Biology · 2016 · https://doi.org/10.1038/ncb3314

• Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon‐like peptide 1 in diet‐induced obesity

  The FASEB Journal · 2015 · https://doi.org/10.1096/fj.14-265983

• Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway

  Oncogene · 2014 · https://doi.org/10.1038/onc.2014.69

• Nuclear receptor PPARγ-regulated monoacylglycerol O -acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis

  Proceedings of the National Academy of Sciences · 2012 · https://doi.org/10.1073/pnas.1203218109

• Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor

  Hepatology · 2012 · https://doi.org/10.1002/hep.26126

• Liver X receptor mediates hepatitis B virus X protein–induced lipogenesis in hepatitis B virus–associated hepatocellular carcinoma #

  Hepatology · 2008 · https://doi.org/10.1002/hep.22740

• Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells

  Oncogene · 2008 · https://doi.org/10.1038/sj.onc.1211000

• Hepatitis B Virus X Protein Enhances Transcriptional Activity of Hypoxia-inducible Factor-1α through Activation of Mitogen-activated Protein Kinase Pathway

  Journal of Biological Chemistry · 2003 · https://doi.org/10.1074/jbc.m305101200

• Inhibitory effect of aqueous extract from the gall of Rhus chinensis on alpha-glucosidase activity and postprandial blood glucose

  Journal of Ethnopharmacology · 2003 · https://doi.org/10.1016/s0378-8741(02)00370-7

• Regulation of the chondrocyte phenotype by β-catenin

  Development · 2002 · https://doi.org/10.1242/dev.129.23.5541

Current projects

No projects listed.