David W. Scott

Research interests

Publications

• The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee

  Blood · 2022 · https://doi.org/10.1182/blood.2022015851

• ROBUST: A Phase III Study of Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma

  Journal of Clinical Oncology · 2021 · https://doi.org/10.1200/jco.20.01366

• Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture

  Nature · 2020 · 10.1038/s41586-020-3017-y

• A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications

  Cancer Cell · 2020 · https://doi.org/10.1016/j.ccell.2020.03.015

• Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

  Cancer Discovery · 2019 · 10.1158/2159-8290.cd-18-1090

• Single-Cell Transcriptome Analysis Reveals Disease-Defining T-cell Subsets in the Tumor Microenvironment of Classic Hodgkin Lymphoma

  Cancer Discovery · 2019 · 10.1158/2159-8290.cd-19-0680

• Prognostic Significance of MYC Rearrangement and Translocation Partner in Diffuse Large B-Cell Lymphoma: A Study by the Lunenburg Lymphoma Biomarker Consortium

  Journal of Clinical Oncology · 2019 · 10.1200/jco.19.00743

• High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements with diffuse large B-cell lymphoma morphology

  Blood · 2018 · 10.1182/blood-2017-12-820605

• Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma

  Journal of Clinical Oncology · 2018 · 10.1200/jco.18.01583

• Clinical Impact of the Cell-of-Origin Classification and the MYC / BCL2 Dual Expresser Status in Diffuse Large B-Cell Lymphoma Treated Within Prospective Clinical Trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group

  Journal of Clinical Oncology · 2017 · 10.1200/jco.2016.70.3660

• Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study

  PLoS Medicine · 2016 · 10.1371/journal.pmed.1002197

• CNS International Prognostic Index: A Risk Model for CNS Relapse in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP

  Journal of Clinical Oncology · 2016 · 10.1200/jco.2015.65.6520

• CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas

  Cancer Discovery · 2016 · 10.1158/2159-8290.cd-16-0975

• The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development

  Nature Medicine · 2015 · 10.1038/nm.3943

• Prognostic Significance of Diffuse Large B-Cell Lymphoma Cell of Origin Determined by Digital Gene Expression in Formalin-Fixed Paraffin-Embedded Tissue Biopsies

  Journal of Clinical Oncology · 2015 · 10.1200/jco.2014.60.2383

• Genomic rearrangements involving programmed death ligands are recurrent in primary mediastinal large B-cell lymphoma

  Blood · 2014 · 10.1182/blood-2013-10-535443

• Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue

  Blood · 2014 · 10.1182/blood-2013-11-536433

• The tumour microenvironment in B cell lymphomas

  Nature reviews. Cancer · 2014 · 10.1038/nrc3774

• Mechanism-Based Epigenetic Chemosensitization Therapy of Diffuse Large B-Cell Lymphoma

  Cancer Discovery · 2013 · 10.1158/2159-8290.cd-13-0117

• EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

  Cancer Cell · 2013 · https://doi.org/10.1016/j.ccr.2013.04.011

• Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing

  Blood · 2013 · 10.1182/blood-2013-02-483727

• Concurrent Expression of MYC and BCL2 in Diffuse Large B-Cell Lymphoma Treated With Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone

  Journal of Clinical Oncology · 2012 · https://doi.org/10.1200/jco.2011.41.0985

• Impact of Concordant and Discordant Bone Marrow Involvement on Outcome in Diffuse Large B-Cell Lymphoma Treated With R-CHOP

  Journal of Clinical Oncology · 2011 · 10.1200/jco.2010.33.3419

• Loss of BAF250a (ARID1A) is frequent in high‐grade endometrial carcinomas

  The Journal of Pathology · 2011 · 10.1002/path.2911

• Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

  Nature · 2011 · https://doi.org/10.1038/nature10351

Current projects

No projects listed.