Tom Eirik Mollnes

Research interests

Publications

• Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation

  Science Immunology · 2021 · 10.1126/sciimmunol.abf2489

• Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics

  Pharmacological Reviews · 2021 · 10.1124/pharmrev.120.000072

• Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients

  Proceedings of the National Academy of Sciences · 2020 · https://doi.org/10.1073/pnas.2010540117

• The Role of Complement in Liver Injury, Regeneration, and Transplantation

  Hepatology · 2019 · 10.1002/hep.30508

• Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions

  ACS Nano · 2019 · 10.1021/acsnano.9b03942

• Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population

  Frontiers in Immunology · 2018 · 10.3389/fimmu.2018.02664

• Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes

  Nature Nanotechnology · 2017 · 10.1038/nnano.2017.47

• Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation

  Mucosal Immunology · 2016 · 10.1038/mi.2016.18

• Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release

  The Journal of Immunology · 2014 · 10.4049/jimmunol.1302484

• An international serum standard for application in assays to detect human complement activation products

  Molecular Immunology · 2013 · 10.1016/j.molimm.2013.05.221

• Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

  Blood · 2010 · 10.1182/blood-2010-02-269746

• The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes

  Immunity · 2010 · 10.1016/j.immuni.2010.09.010

• Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study

  European Respiratory Journal · 2009 · 10.1183/09031936.00088209

• Innate Immune Responses to Danger Signals in Systemic Inflammatory Response Syndrome and Sepsis

  Scandinavian Journal of Immunology · 2009 · 10.1111/j.1365-3083.2009.02255.x

• The alternative complement pathway revisited

  Journal of Cellular and Molecular Medicine · 2008 · 10.1111/j.1582-4934.2008.00350.x

• Complement and coagulation: strangers or partners in crime?

  Trends in Immunology · 2007 · 10.1016/j.it.2007.02.006

• The role of complement in biomaterial-induced inflammation

  Molecular Immunology · 2006 · 10.1016/j.molimm.2006.06.020

• Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA

  Journal of Immunological Methods · 2004 · 10.1016/j.jim.2004.11.016

• The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation

  Clinical & Experimental Immunology · 2004 · 10.1111/j.1365-2249.2004.02627.x

• Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation.

  PubMed · 2002 · 10.1182/blood.v100.5.1869.h81702001869_1869_1877

• Hereditary porcine membranoproliferative glomerulonephritis type II is caused by factor H deficiency.

  Journal of Clinical Investigation · 1995 · 10.1172/jci117751

• Reduced complement activation with heparin-coated oxygenator and tubings in coronary bypass operations

  Journal of Thoracic and Cardiovascular Surgery · 1992 · 10.1016/s0022-5223(19)34966-9

• Complement-Mediated Demyelination in Patients with IgM Monoclonal Gammopathy and Polyneuropathy

  New England Journal of Medicine · 1990 · 10.1056/nejm199003083221002

• Complement Activation and Endotoxin Levels in Systemic Meningococcal Disease

  The Journal of Infectious Diseases · 1989 · 10.1093/infdis/160.1.58

• Quantification of the Terminal Complement Complex in Human Plasma by an Enzyme‐Linked Immunosorbent Assay Based on Monoclonal Antibodies against a Neoantigen of the Complex

  Scandinavian Journal of Immunology · 1985 · 10.1111/j.1365-3083.1985.tb01871.x

Current projects

No projects listed.