Hiroyuki Mizuguchi

Research interests

Publications

• Adenovirus vector-based vaccine for infectious diseases

  Drug Metabolism and Pharmacokinetics · 2021 · 10.1016/j.dmpk.2021.100432

• Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure

  Journal of Hepatology · 2016 · 10.1016/j.jhep.2016.01.004

• Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes

  Proceedings of the National Academy of Sciences · 2014 · 10.1073/pnas.1413481111

• Protective mucosal immunity mediated by epithelial CD1d and IL-10

  Nature · 2014 · 10.1038/nature13150

• Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction

  Journal of Hepatology · 2012 · 10.1016/j.jhep.2012.04.038

• 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

  Biomaterials · 2012 · https://doi.org/10.1016/j.biomaterials.2012.11.029

• Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction

  Molecular Therapy · 2011 · 10.1038/mt.2011.234

• Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells

  Cancer Gene Therapy · 2007 · 10.1038/sj.cgt.7701079

• Targeted Delivery of CX3CL1 to Multiple Lung Tumors by Mesenchymal Stem Cells

  Stem Cells · 2007 · 10.1634/stemcells.2006-0461

• Innate immune response induced by gene delivery vectors

  International Journal of Pharmaceutics · 2007 · 10.1016/j.ijpharm.2007.06.012

• Neuronal Pathway from the Liver Modulates Energy Expenditure and Systemic Insulin Sensitivity

  Science · 2006 · https://doi.org/10.1126/science.1126010

• In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus

  Nature Medicine · 2006 · 10.1038/nm1404

• Quantitative Comparison of Intracellular Trafficking and Nuclear Transcription between Adenoviral and Lipoplex Systems

  Molecular Therapy · 2005 · 10.1016/j.ymthe.2005.10.007

• Targeted Adenovirus Vectors

  Human Gene Therapy · 2004 · 10.1089/hum.2004.15.1034

• A Novel Strategy for the Enhancement of Drug Absorption Using a Claudin Modulator

  Molecular Pharmacology · 2004 · 10.1124/mol.104.008375

• A novel PPARγ gene therapy to control inflammation associated with inflammatory bowel disease in a murine model

  Gastroenterology · 2003 · 10.1016/s0016-5085(03)00262-2

• Autoinhibitory Regulation of p73 by ΔNp73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ΔNp73 Promoter

  Molecular and Cellular Biology · 2002 · 10.1128/mcb.22.8.2575-2585.2002

• A Novel Murine Model of Graves’ Hyperthyroidism with Intramuscular Injection of Adenovirus Expressing the Thyrotropin Receptor

  The Journal of Immunology · 2002 · 10.4049/jimmunol.168.6.2789

• A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob

  Gene Therapy · 2001 · 10.1038/sj.gt.3301453

• Optimization of transcriptional regulatory elements for constructing plasmid vectors

  Gene · 2001 · 10.1016/s0378-1119(01)00550-9

• IRES-Dependent Second Gene Expression Is Significantly Lower Than Cap-Dependent First Gene Expression in a Bicistronic Vector

  Molecular Therapy · 2000 · https://doi.org/10.1006/mthe.2000.0050

• A Simple Method for Constructing E1- and E1/E4-Deleted Recombinant Adenoviral Vectors

  Human Gene Therapy · 1999 · https://doi.org/10.1089/10430349950017374

• Efficient Construction of a Recombinant Adenovirus Vector by an Improved In Vitro Ligation Method

  Human Gene Therapy · 1998 · https://doi.org/10.1089/hum.1998.9.17-2577

• Molecular Cloning of the Human Histamine H1 Receptor Gene

  Biochemical and Biophysical Research Communications · 1994 · 10.1006/bbrc.1994.1786

• Expression cloning of a cDNA encoding the bovine histamine H1 receptor.

  Proceedings of the National Academy of Sciences · 1991 · 10.1073/pnas.88.24.11515

Current projects

No projects listed.