Cheng Luo

Research interests

Publications

• YTHDF2 inhibition potentiates radiotherapy antitumor efficacy

  Cancer Cell · 2023 · 10.1016/j.ccell.2023.04.019

• Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1

  Signal Transduction and Targeted Therapy · 2023 · https://doi.org/10.1038/s41392-022-01231-4

• Structural basis of ketamine action on human NMDA receptors

  Nature · 2021 · https://doi.org/10.1038/s41586-021-03769-9

• Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors

  Journal of Medicinal Chemistry · 2020 · https://doi.org/10.1021/acs.jmedchem.9b01721

• Targeting p300/CBP Attenuates Hepatocellular Carcinoma Progression through Epigenetic Regulation of Metabolism

  Cancer Research · 2020 · https://doi.org/10.1158/0008-5472.can-20-1323

• Identification of recurrent USP48 and BRAF mutations in Cushing’s disease

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-05275-5

• Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes

  American Journal of Clinical Nutrition · 2017 · https://doi.org/10.3945/ajcn.117.157107

• The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.09.051

• Biotin-tagged platinum( iv ) complexes as targeted cytostatic agents against breast cancer cells

  Chemical Communications · 2017 · https://doi.org/10.1039/c7cc05311h

• Adverse childhood experiences and risk of type 2 diabetes: A systematic review and meta-analysis

  Metabolism · 2015 · 10.1016/j.metabol.2015.08.019

• Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

  Nature Chemistry · 2015 · https://doi.org/10.1038/nchem.2381

• Structural insight into substrate preference for TET-mediated oxidation

  Nature · 2015 · 10.1038/nature15713

• In silico ADME/T modelling for rational drug design

  Quarterly Reviews of Biophysics · 2015 · https://doi.org/10.1017/s0033583515000190

• Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

  Nucleic Acids Research · 2014 · https://doi.org/10.1093/nar/gku1276

• Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

  Nature Neuroscience · 2014 · https://doi.org/10.1038/nn.3728

• Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase

  Proceedings of the National Academy of Sciences · 2014 · https://doi.org/10.1073/pnas.1408601111

• Nut consumption and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis

  American Journal of Clinical Nutrition · 2014 · 10.3945/ajcn.113.076109

• Computational drug discovery

  Acta Pharmacologica Sinica · 2012 · 10.1038/aps.2012.109

• Development of Cell-Active N 6 -Methyladenosine RNA Demethylase FTO Inhibitor

  Journal of the American Chemical Society · 2012 · https://doi.org/10.1021/ja3064149

• Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA

  Nature Chemical Biology · 2012 · 10.1038/nchembio.914

• Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance

  Proceedings of the National Academy of Sciences · 2012 · https://doi.org/10.1073/pnas.1205952109

• Extensive Crosstalk between O-GlcNAcylation and Phosphorylation Regulates Akt Signaling

  PLoS ONE · 2012 · https://doi.org/10.1371/journal.pone.0037427

• Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

  Nature · 2010 · https://doi.org/10.1038/nature09128

• Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

  Science · 2009 · https://doi.org/10.1126/science.1176709

• Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure–activity relationship studies reveal salient pharmacophore features

  Bioorganic & Medicinal Chemistry · 2006 · https://doi.org/10.1016/j.bmc.2006.09.014

Current projects

No projects listed.