Jian Ding

Research interests

Publications

• A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia

  Alzheimer s Research & Therapy · 2021 · https://doi.org/10.1186/s13195-021-00795-7

• Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

  Molecular Cancer · 2020 · https://doi.org/10.1186/s12943-020-01202-9

• Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-019-10427-2

• Oncogene-induced senescence: a double edged sword in cancer

  Acta Pharmacologica Sinica · 2018 · https://doi.org/10.1038/aps.2017.198

• Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.08.058

• G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin

  Nature Communications · 2017 · https://doi.org/10.1038/s41467-017-00350-9

• Aspirin Inhibits Cancer Metastasis and Angiogenesis via Targeting Heparanase

  Clinical Cancer Research · 2017 · https://doi.org/10.1158/1078-0432.ccr-17-0242

• Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.08.001

• Alterations of functional and structural connectivity of freezing of gait in Parkinson’s disease

  Journal of Neurology · 2016 · https://doi.org/10.1007/s00415-016-8174-4

• PI3K isoform-selective inhibitors: next-generation targeted cancer therapies

  Acta Pharmacologica Sinica · 2015 · https://doi.org/10.1038/aps.2015.71

• Molecularly targeted cancer therapy: some lessons from the past decade

  Trends in Pharmacological Sciences · 2013 · https://doi.org/10.1016/j.tips.2013.11.004

• Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

  Natural Product Reports · 2012 · https://doi.org/10.1039/c2np00088a

• Extensive Crosstalk between O-GlcNAcylation and Phosphorylation Regulates Akt Signaling

  PLoS ONE · 2012 · https://doi.org/10.1371/journal.pone.0037427

• The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells

  Investigational New Drugs · 2010 · https://doi.org/10.1007/s10637-010-9481-8

• A Series of α-Heterocyclic Carboxaldehyde Thiosemicarbazones Inhibit Topoisomerase IIα Catalytic Activity

  Journal of Medicinal Chemistry · 2010 · https://doi.org/10.1021/jm9014394

• Enhanced expression of Duffy antigen receptor for chemokines by breast cancer cells attenuates growth and metastasis potential

  Oncogene · 2006 · https://doi.org/10.1038/sj.onc.1209703

• Emerging cancer therapeutic opportunities target DNA-repair systems

  Trends in Pharmacological Sciences · 2006 · https://doi.org/10.1016/j.tips.2006.04.007

• A novel cytotoxic ternary copper(II) complex of 1,10-phenanthroline and l-threonine with DNA nuclease activity

  Journal of Inorganic Biochemistry · 2004 · https://doi.org/10.1016/j.jinorgbio.2004.09.014

• Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms

  Neuroscience Letters · 2004 · https://doi.org/10.1016/j.neulet.2004.10.063

• Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well-known TCM plant Daphne genkwa

  Bioorganic & Medicinal Chemistry · 2004 · https://doi.org/10.1016/j.bmc.2004.10.054

• Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential

  European Journal of Pharmacology · 2003 · https://doi.org/10.1016/s0014-2999(02)02848-0

Current projects

No projects listed.