Ragnhild A. Lothe

Research interests

Publications

• Biomarker-guided therapy for colorectal cancer: strength in complexity

  Nature Reviews Clinical Oncology · 2019 · https://doi.org/10.1038/s41571-019-0241-1

• Relative contribution of clinicopathological variables, genomic markers, transcriptomic subtyping and microenvironment features for outcome prediction in stage II/III colorectal cancer

  Annals of Oncology · 2019 · https://doi.org/10.1093/annonc/mdz287

• CMScaller: an R package for consensus molecular subtyping of colorectal cancer pre-clinical models

  Scientific Reports · 2017 · https://doi.org/10.1038/s41598-017-16747-x

• Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies

  Molecular Cancer · 2017 · https://doi.org/10.1186/s12943-017-0691-y

• Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies

  Clinical Cancer Research · 2017 · https://doi.org/10.1158/1078-0432.ccr-17-1234

• Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study

  Annals of Oncology · 2017 · https://doi.org/10.1093/annonc/mdx052

• Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study

  ˜The œLancet. Gastroenterology & hepatology · 2016 · https://doi.org/10.1016/s2468-1253(16)30014-0

• Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes

  Oncogene · 2015 · https://doi.org/10.1038/onc.2015.318

• Portrait of the PI3K/AKT pathway in colorectal cancer

  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · 2014 · https://doi.org/10.1016/j.bbcan.2014.09.008

• Epigenetic and genetic features of 24 colon cancer cell lines

  Oncogenesis · 2013 · https://doi.org/10.1038/oncsis.2013.35

• Oncogenicity of the Developmental Transcription Factor Sox9

  Cancer Research · 2012 · https://doi.org/10.1158/0008-5472.can-11-3660

• Survival meta-analyses for >1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1

  Neuro-Oncology · 2012 · https://doi.org/10.1093/neuonc/nos287

• Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection: results from a large, consecutive Norwegian series

  Annals of Oncology · 2012 · https://doi.org/10.1093/annonc/mds614

• ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis

  Gut · 2012 · https://doi.org/10.1136/gutjnl-2011-301179

• Autophagy in tumour suppression and promotion

  Molecular Oncology · 2009 · https://doi.org/10.1016/j.molonc.2009.05.007

• Cisplatin-Induced Long-Term Hearing Impairment Is Associated With Specific Glutathione S-Transferase Genotypes in Testicular Cancer Survivors

  Journal of Clinical Oncology · 2007 · https://doi.org/10.1200/jco.2006.08.9599

• Differentiation of Human Embryonal Carcinomas In vitro and In vivo Reveals Expression Profiles Relevant to Normal Development

  Cancer Research · 2005 · https://doi.org/10.1158/0008-5472.can-05-0153

• The order of genetic events associated with colorectal cancer progression inferred from meta‐analysis of copy number changes

  Genes Chromosomes and Cancer · 2005 · https://doi.org/10.1002/gcc.20261

• The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas.

  PubMed · 2002

• Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma

  International Journal of Cancer · 2001 · https://doi.org/10.1002/ijc.1205

• Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome

  Oncogene · 2000 · https://doi.org/10.1038/sj.onc.1203227

• Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites

  Genes Chromosomes and Cancer · 1998 · https://doi.org/10.1002/(sici)1098-2264(199802)21:2<101::aid-gcc4>3.0.co;2-4

• Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors

  International Journal of Cancer · 1997 · https://doi.org/10.1002/(sici)1097-0215(19971219)74:6<664::aid-ijc18>3.0.co;2-5

• Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.

  PubMed · 1993

• Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.

  PubMed · 1993

Current projects

No projects listed.