Michael McMahon

Research interests

Publications

• Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

  Oncogene · 2012 · 10.1038/onc.2012.388

• SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

  Molecular and Cellular Biology · 2011 · https://doi.org/10.1128/mcb.01204-10

• Chronic pancreatitis

  The Lancet · 2011 · 10.1016/s0140-6736(10)61852-1

• Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

  Antioxidants and Redox Signaling · 2010 · 10.1089/ars.2010.3221

• p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

  Journal of Biological Chemistry · 2010 · https://doi.org/10.1074/jbc.m110.118976

• Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

  Proceedings of the National Academy of Sciences · 2010 · 10.1073/pnas.1007387107

• Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

  Carcinogenesis · 2009 · 10.1093/carcin/bgp176

• NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

  Trends in Biochemical Sciences · 2009 · https://doi.org/10.1016/j.tibs.2008.12.008

• Dimerization of Substrate Adaptors Can Facilitate Cullin-mediated Ubiquitylation of Proteins by a “Tethering” Mechanism

  Journal of Biological Chemistry · 2006 · 10.1074/jbc.m601119200

• Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice

  Hepatology · 2004 · 10.1002/hep.20183

• Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

  Archives of Biochemistry and Biophysics · 2004 · 10.1016/j.abb.2004.10.012

• Psychosocial Factors and Preterm Birth Among African American and White Women in Central North Carolina

  American Journal of Public Health · 2004 · 10.2105/ajph.94.8.1358

• Redox-regulated Turnover of Nrf2 Is Determined by at Least Two Separate Protein Domains, the Redox-sensitive Neh2 Degron and the Redox-insensitive Neh6 Degron

  Journal of Biological Chemistry · 2004 · 10.1074/jbc.m403061200

• Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

  Biochemical Journal · 2003 · 10.1042/bj20030754

• Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

  Journal of Biological Chemistry · 2003 · https://doi.org/10.1074/jbc.m300931200

• Metal Levels in Fish from the Savannah River: Potential Hazards to Fish and Other Receptors

  Environmental Research · 2002 · 10.1006/enrs.2002.4330

• Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

  Biochemical Journal · 2002 · 10.1042/bj20020320

• The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

  PubMed · 2001

• The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

  Biochemical Society Transactions · 2000 · 10.1042/bst0280033

• Hemodynamic consequences of high- and low-pressure capnoperitoneum during laparoscopic cholecystectomy

  Surgical Endoscopy · 1999 · 10.1007/s004649900993

• Diagnosis, objective assessment of severity, and management of acute pancreatitis

  International Journal of Pancreatology · 1999 · 10.1007/bf02925968

• Early increase in intestinal permeability in patients with severe acute pancreatitis: correlation with endotoxemia, organ failure, and mortality

  Journal of Gastrointestinal Surgery · 1999 · 10.1016/s1091-255x(99)80067-5

• Trauma and Pregnancy

  American Journal of Perinatology · 1997 · 10.1055/s-2007-994155

• Comparison of a Trial of Labor with an Elective Second Cesarean Section

  New England Journal of Medicine · 1996 · https://doi.org/10.1056/nejm199609053351001

• Controlled Clinical Trial of Peritoneal Lavage for the Treatment of Severe Acute Pancreatitis

  New England Journal of Medicine · 1985 · 10.1056/nejm198502143120703

Current projects

No projects listed.