Steffen Thiel

Research interests

Publications

• Complement activation, regulation, and molecular basis for complement‐related diseases

  The EMBO Journal · 2015 · 10.15252/embj.201591881

• Cystic Fibrosis Sputum DNA Has NETosis Characteristics and Neutrophil Extracellular Trap Release Is Regulated by Macrophage Migration-Inhibitory Factor

  Journal of Innate Immunity · 2014 · 10.1159/000363242

• Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins

  Molecular Immunology · 2007 · 10.1016/j.molimm.2007.06.005

• Clinical manifestations of mannan-binding lectin deficiency

  Molecular Immunology · 2005 · 10.1016/j.molimm.2005.06.018

• Effect of Capsulation of Opportunistic Pathogenic Bacteria on Binding of the Pattern Recognition Molecules Mannan-Binding Lectin, L-Ficolin, and H-Ficolin

  Infection and Immunity · 2005 · 10.1128/iai.73.2.1052-1060.2005

• Mannose-binding Lectin-deficient Mice Are Susceptible to Infection with Staphylococcus aureus

  The Journal of Experimental Medicine · 2004 · 10.1084/jem.20032207

• L-ficolin Is a Pattern Recognition Molecule Specific for Acetyl Groups

  Journal of Biological Chemistry · 2004 · 10.1074/jbc.m407161200

• Collectins and Ficolins: Humoral Lectins of the Innate Immune Defense

  Annual Review of Immunology · 2003 · https://doi.org/10.1146/annurev.immunol.21.120601.140954

• Inherited Deficiency of Mannan-Binding Lectin–Associated Serine Protease 2

  New England Journal of Medicine · 2003 · 10.1056/nejmoa022836

• Intensive Insulin Therapy Exerts Antiinflammatory Effects in Critically Ill Patients and Counteracts the Adverse Effect of Low Mannose-Binding Lectin Levels

  The Journal of Clinical Endocrinology & Metabolism · 2003 · https://doi.org/10.1210/jc.2002-021478

• MASP-3 and Its Association with Distinct Complexes of the Mannan-Binding Lectin Complement Activation Pathway

  Immunity · 2001 · https://doi.org/10.1016/s1074-7613(01)00161-3

• An assay for the mannan-binding lectin pathway of complement activation

  Journal of Immunological Methods · 2001 · 10.1016/s0022-1759(01)00453-7

• Association between deficiency of mannose-binding lectin and severe infections after chemotherapy

  The Lancet · 2001 · 10.1016/s0140-6736(01)05785-3

• Purification and Characterization of Two Mannan-Binding Lectins from Mouse Serum

  The Journal of Immunology · 2000 · https://doi.org/10.4049/jimmunol.164.5.2610

• Distinct Pathways of Mannan-Binding Lectin (MBL)- and C1-Complex Autoactivation Revealed by Reconstitution of MBL with Recombinant MBL-Associated Serine Protease-2

  The Journal of Immunology · 2000 · 10.4049/jimmunol.165.4.2093

• Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers

  Journal of Immunological Methods · 2000 · 10.1016/s0022-1759(00)00198-8

• Proteolytic Activities of Two Types of Mannose-Binding Lectin-Associated Serine Protease

  The Journal of Immunology · 2000 · 10.4049/jimmunol.165.5.2637

• Two Constituents of the Initiation Complex of the Mannan-Binding Lectin Activation Pathway of Complement Are Encoded by a Single Structural Gene

  The Journal of Immunology · 1999 · 10.4049/jimmunol.162.6.3481

• A second serine protease associated with mannan-binding lectin that activates complement

  Nature · 1997 · https://doi.org/10.1038/386506a0

• Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein

  The Journal of Immunology · 1995 · https://doi.org/10.4049/jimmunol.155.6.3013

• A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein

  Immunogenetics · 1994 · 10.1007/bf00163962

• The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response

  Clinical & Experimental Immunology · 1992 · 10.1111/j.1365-2249.1992.tb05827.x

• Human leukocyte C1q receptor binds other soluble proteins with collagen domains.

  The Journal of Experimental Medicine · 1990 · 10.1084/jem.172.3.955

• Binding of the pentamer/hexamer forms of mannan-binding protein to zymosan activates the proenzyme C1r2C1s2 complex, of the classical pathway of complement, without involvement of C1q.

  The Journal of Immunology · 1990 · 10.4049/jimmunol.144.6.2287

• ASSOCIATION OF LOW LEVELS OF MANNAN-BINDING PROTEIN WITH A COMMON DEFECT OF OPSONISATION

  The Lancet · 1989 · https://doi.org/10.1016/s0140-6736(89)91849-7

• Structures and functions associated with the group of mammalian lectins containing collagen‐like sequences

  FEBS Letters · 1989 · 10.1016/0014-5793(89)80689-1

Current projects

No projects listed.