Lin Lin

Research interests

Publications

• A compendium of genetic regulatory effects across pig tissues

  Nature Genetics · 2024 · https://doi.org/10.1038/s41588-023-01585-7

• Single‐cell RNA sequencing technologies and applications: A brief overview

  Clinical and Translational Medicine · 2022 · https://doi.org/10.1002/ctm2.694

• Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-021-23576-0

• An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

  Cancer Cell · 2020 · https://doi.org/10.1016/j.ccell.2019.12.001

• Single-Cell Transcriptome Atlas of Murine Endothelial Cells

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.01.015

• Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis

  Cell Metabolism · 2020 · https://doi.org/10.1016/j.cmet.2020.03.009

• An atlas of the protein-coding genes in the human, pig, and mouse brain

  Science · 2020 · https://doi.org/10.1126/science.aay5947

• Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation

  Journal of the American Society of Nephrology · 2019 · https://doi.org/10.1681/asn.2019080832

• Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease

  Brain · 2019 · https://doi.org/10.1093/brain/awy354

• Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-05861-7

• Chromatin accessibility and guide sequence secondary structure affect CRISPR ‐Cas9 gene editing efficiency

  FEBS Letters · 2017 · https://doi.org/10.1002/1873-3468.12707

• Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

  Science · 2017 · https://doi.org/10.1126/science.aan4187

• Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2591

• DNA Origami as a Carrier for Circumvention of Drug Resistance

  Journal of the American Chemical Society · 2012 · https://doi.org/10.1021/ja304263n

• Adsorption mechanisms of high-levels of ammonium onto natural and NaCl-modified zeolites

  Separation and Purification Technology · 2012 · https://doi.org/10.1016/j.seppur.2012.10.005

• Steroidogenic factor-1 (SF-1, NR5A1) and human disease

  Molecular and Cellular Endocrinology · 2010 · https://doi.org/10.1016/j.mce.2010.11.006

• Human Male Infertility Associated with Mutations in NR5A1 Encoding Steroidogenic Factor 1

  The American Journal of Human Genetics · 2010 · https://doi.org/10.1016/j.ajhg.2010.09.009

• Mutations in NR5A1 Associated with Ovarian Insufficiency

  New England Journal of Medicine · 2009 · https://doi.org/10.1056/nejmoa0806228

• SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.465

• Heterozygous Missense Mutations in Steroidogenic Factor 1 (SF1/Ad4BP, NR5A1) Are Associated with 46,XY Disorders of Sex Development with Normal Adrenal Function

  The Journal of Clinical Endocrinology & Metabolism · 2007 · https://doi.org/10.1210/jc.2006-1672

• Analysis of DAX1 (NR0B1) and Steroidogenic Factor-1 (NR5A1) in Children and Adults with Primary Adrenal Failure: Ten Years’ Experience

  The Journal of Clinical Endocrinology & Metabolism · 2006 · https://doi.org/10.1210/jc.2006-0603

• Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene

  Oncogene · 2003 · https://doi.org/10.1038/sj.onc.1207300

• Agricultural Productivity Growth and Poverty Alleviation

  Development Policy Review · 2001 · https://doi.org/10.1111/1467-7679.00144

Current projects

No projects listed.