Jesper Wengel

Research interests

Publications

• Synthetic Genetic Polymers Capable of Heredity and Evolution

  Science · 2012 · https://doi.org/10.1126/science.1217622

• Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals

  Chemical Society Reviews · 2011 · https://doi.org/10.1039/c1cs15048k

• Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer

  Nucleic Acids Research · 2010 · https://doi.org/10.1093/nar/gkq823

• Locked Nucleic Acids: Promising Nucleic Acid Analogs for Therapeutic Applications

  Chemistry & Biodiversity · 2010 · https://doi.org/10.1002/cbdv.200900343

• A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

  Nucleic Acids Research · 2010 · https://doi.org/10.1093/nar/gkq341

• The Effect of Chemical Modification and Nanoparticle Formulation on Stability and Biodistribution of siRNA in Mice

  Molecular Therapy · 2009 · https://doi.org/10.1038/mt.2009.91

• A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

  Nucleic Acids Research · 2009 · https://doi.org/10.1093/nar/gkp106

• Improved silencing properties using small internally segmented interfering RNAs

  Nucleic Acids Research · 2007 · https://doi.org/10.1093/nar/gkm548

• LNA (Locked Nucleic Acid): High-Affinity Targeting of Complementary RNA and DNA

  Biochemistry · 2004 · https://doi.org/10.1021/bi0485732

• Locked Nucleic Acid: A Potent Nucleic Acid Analog in Therapeutics and Biotechnology

  Oligonucleotides · 2004 · https://doi.org/10.1089/1545457041526317

• LNA: a versatile tool for therapeutics and genomics

  Trends in biotechnology · 2003 · https://doi.org/10.1016/s0167-7799(02)00038-0

• Locked Nucleic Acid (LNA) Recognition of RNA: NMR Solution Structures of LNA:RNA Hybrids

  Journal of the American Chemical Society · 2002 · https://doi.org/10.1021/ja012288d

• Structural Studies of LNA:RNA Duplexes by NMR: Conformations and Implications for RNase H Activity

  Chemistry - A European Journal · 2000 · https://doi.org/10.1002/1521-3765(20000804)6:15<2687::aid-chem2687>3.0.co;2-u

• The conformations of locked nucleic acids (LNA)

  Journal of Molecular Recognition · 2000 · https://doi.org/10.1002/(sici)1099-1352(200001/02)13:1<44::aid-jmr486>3.0.co;2-6

• Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

  Proceedings of the National Academy of Sciences · 2000 · https://doi.org/10.1073/pnas.97.10.5633

• Synthesis of 3‘-C- and 4‘-C-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA)

  Accounts of Chemical Research · 1998 · https://doi.org/10.1021/ar980051p

• LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

  Tetrahedron · 1998 · https://doi.org/10.1016/s0040-4020(98)00094-5

• The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNA

  Bioorganic & Medicinal Chemistry Letters · 1998 · https://doi.org/10.1016/s0960-894x(98)00366-7

• LNA (Locked Nucleic Acid): An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes

  Journal of the American Chemical Society · 1998 · https://doi.org/10.1021/ja9822862

• LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

  Chemical Communications · 1998 · https://doi.org/10.1039/a708608c

• Phytochemistry of the genus Piper

  Phytochemistry · 1997 · https://doi.org/10.1016/s0031-9422(97)00328-2

Current projects

No projects listed.