Sirpa Leppä

Research interests

Publications

• Molecular features encoded in the ctDNA reveal heterogeneity and predict outcome in high-risk aggressive B-cell lymphoma

  Blood · 2021 · https://doi.org/10.1182/blood.2021012852

• Immunogenomic Landscape of Hematological Malignancies

  Cancer Cell · 2020 · https://doi.org/10.1016/j.ccell.2020.06.002

• Sustained Progression-Free Survival Benefit of Rituximab Maintenance in Patients With Follicular Lymphoma: Long-Term Results of the PRIMA Study

  Journal of Clinical Oncology · 2019 · https://doi.org/10.1200/jco.19.01073

• Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Non–Germinal Center B-Cell Diffuse Large B-Cell Lymphoma

  Journal of Clinical Oncology · 2019 · https://doi.org/10.1200/jco.18.02403

• Ofatumumab Versus Rituximab Salvage Chemoimmunotherapy in Relapsed or Refractory Diffuse Large B-Cell Lymphoma: The ORCHARRD Study

  Journal of Clinical Oncology · 2017 · https://doi.org/10.1200/jco.2016.69.0198

• Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.09.027

• Phosphatidylinositol 3-Kinase Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma

  Journal of Clinical Oncology · 2017 · https://doi.org/10.1200/jco.2017.75.4648

• FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders

  Neurology · 2016 · https://doi.org/10.1212/wnl.0000000000003374

• Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells

  Nature Communications · 2015 · https://doi.org/10.1038/ncomms7025

• Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial

  The Lancet · 2010 · https://doi.org/10.1016/s0140-6736(10)62175-7

• A High Tumor-Associated Macrophage Content Predicts Favorable Outcome in Follicular Lymphoma Patients Treated with Rituximab and Cyclophosphamide-Doxorubicin-Vincristine-Prednisone

  Clinical Cancer Research · 2007 · https://doi.org/10.1158/1078-0432.ccr-07-0778

• Prognostic impact of immunohistochemically defined germinal center phenotype in diffuse large B-cell lymphoma patients treated with immunochemotherapy

  Blood · 2007 · https://doi.org/10.1182/blood-2006-09-047068

• Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

  Oncogene · 1999 · https://doi.org/10.1038/sj.onc.1203173

• Differential regulation of c‐Jun by ERK and JNK during PC12 cell differentiation

  The EMBO Journal · 1998 · https://doi.org/10.1093/emboj/17.15.4404

Current projects

No projects listed.