Charles Brenner

Research interests

Publications

• Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

  Nature Metabolism · 2020 · https://doi.org/10.1038/s42255-020-00305-3

• Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy

  Cell Metabolism · 2020 · https://doi.org/10.1016/j.cmet.2020.04.008

• Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

  Cell Reports · 2019 · https://doi.org/10.1016/j.celrep.2019.07.043

• Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

  Cell Metabolism · 2018 · https://doi.org/10.1016/j.cmet.2018.02.001

• A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

  American Journal of Clinical Nutrition · 2018 · https://doi.org/10.1093/ajcn/nqy132

• Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.07.042

• Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy

  Circulation · 2017 · https://doi.org/10.1161/circulationaha.116.026099

• Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

  Scientific Reports · 2016 · https://doi.org/10.1038/srep26933

• Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms12948

• NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms13103

• Microbial NAD Metabolism: Lessons from Comparative Genomics

  Microbiology and Molecular Biology Reviews · 2009 · https://doi.org/10.1128/mmbr.00042-08

• Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD + Precursor Vitamins in Human Nutrition

  Annual Review of Nutrition · 2008 · https://doi.org/10.1146/annurev.nutr.28.061807.155443

• Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+

  Cell · 2007 · https://doi.org/10.1016/j.cell.2007.03.024

• ISFG: Recommendations on biostatistics in paternity testing

  Forensic Science International Genetics · 2007 · https://doi.org/10.1016/j.fsigen.2007.06.006

• p53 Activation by Knockdown Technologies

  PLoS Genetics · 2007 · https://doi.org/10.1371/journal.pgen.0030078

• Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

  Cell · 2006 · https://doi.org/10.1016/j.cell.2006.06.040

• DNA commission of the International Society of Forensic Genetics: Recommendations on the interpretation of mixtures

  Forensic Science International · 2006 · https://doi.org/10.1016/j.forsciint.2006.04.009

• NAD+ metabolism in health and disease

  Trends in Biochemical Sciences · 2006 · https://doi.org/10.1016/j.tibs.2006.11.006

• Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans

  Cell · 2004 · https://doi.org/10.1016/s0092-8674(04)00416-7

• Hint, Fhit, and GalT: Function, Structure, Evolution, and Mechanism of Three Branches of the Histidine Triad Superfamily of Nucleotide Hydrolases and Transferases

  Biochemistry · 2002 · https://doi.org/10.1021/bi025942q

• The nitrilase superfamily: classification, structure and function.

  Genome biology · 2001 · https://doi.org/10.1186/gb-2001-2-1-reviews0001

• GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

  Cell · 1987 · https://doi.org/10.1016/0092-8674(87)90167-x

• The mind in conflict

  Medical Entomology and Zoology · 1982

• An elementary textbook of psychoanalysis

  Journal · 1955

Current projects

No projects listed.