Pekka T. Männistö

Research interests

Publications

• Catechol-O-methyltransferase gene polymorphism and chronic human pain

  Pharmacogenetics and Genomics · 2012 · 10.1097/fpc.0b013e3283560c46

• Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease

  Experimental Neurology · 2010 · 10.1016/j.expneurol.2010.12.013

• Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice

  Journal of Neurochemistry · 2010 · 10.1111/j.1471-4159.2010.06889.x

• The multiple faces of quercetin in neuroprotection

  Expert Opinion on Drug Safety · 2009 · 10.1517/14740330903026944

• Site-Specific Role of Catechol- O -Methyltransferase in Dopamine Overflow within Prefrontal Cortex and Dorsal Striatum

  Journal of Neuroscience · 2007 · https://doi.org/10.1523/jneurosci.0665-07.2007

• Pharmacologically Diverse Antidepressants Rapidly Activate Brain-Derived Neurotrophic Factor Receptor TrkB and Induce Phospholipase-Cγ Signaling Pathways in Mouse Brain

  Neuropsychopharmacology · 2007 · https://doi.org/10.1038/sj.npp.1301345

• On the role of prolyl oligopeptidase in health and disease

  Neuropeptides · 2006 · 10.1016/j.npep.2006.10.004

• Dopamine supersensitivity correlates with D2 High states, implying many paths to psychosis

  Proceedings of the National Academy of Sciences · 2005 · https://doi.org/10.1073/pnas.0409766102

• Brain catecholamine metabolism in catechol‐O‐methyltransferase (COMT)‐deficient mice

  European Journal of Neuroscience · 2002 · 10.1046/j.0953-816x.2001.01856.x

• Catechol-O-methyltransferase (COMT): Biochemistry, Molecular Biology, Pharmacology, and Clinical Efficacy of the New Selective COMT Inhibitors

  Pharmacological Reviews · 1999 · https://doi.org/10.1016/s0031-6997(24)01423-6

• 7-Nitroindazole, a nitric oxide synthase inhibitor, has anxiolytic-like properties in exploratory models of anxiety

  Psychopharmacology · 1997 · 10.1007/s002130050309

• General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase

  General Pharmacology The Vascular System · 1994 · 10.1016/0306-3623(94)90082-5

• Characteristics of catechol O-methyltransferase (COMT) and properties of selective COMT inhibitors

  Birkhäuser Basel eBooks · 1992 · https://doi.org/10.1007/978-3-0348-7144-0_9

• Rationale for Selective COMT Inhibitors as Adjuncts in the Drug Treatment of Parkinson's Disease

  Pharmacology & Toxicology · 1990 · 10.1111/j.1600-0773.1990.tb00756.x

• Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors

  Journal of Medicinal Chemistry · 1989 · 10.1021/jm00124a017

• New selective COMT inhibitors: useful adjuncts for Parkinson's disease?

  Trends in Pharmacological Sciences · 1989 · 10.1016/0165-6147(89)90075-8

• Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat

  European Journal of Pharmacology · 1988 · 10.1016/0014-2999(88)90614-0

• Neurotransmitter regulation of anterior pituitary hormones.

  PubMed · 1985

Current projects

No projects listed.