Adam Nelson

Research interests

Publications

• Complement blockade for TA-TMA: lessons learned from large pediatric cohort treated with eculizumab

  Blood · 2020 · 10.1182/blood.2019004218

• A pragmatic multi-institutional approach to understanding transplant-associated thrombotic microangiopathy after stem cell transplant

  Blood Advances · 2020 · 10.1182/bloodadvances.2020003455

• Virus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients.

  PubMed · 2020 · 10.1182/bloodadvances.2020003073

• Predicting and Experimentally Validating Hot-Spot Residues at Protein–Protein Interfaces

  ACS Chemical Biology · 2019 · 10.1021/acschembio.9b00560

• Ruxolitinib as Salvage Therapy in Steroid-Refractory Acute Graft-versus-Host Disease in Pediatric Hematopoietic Stem Cell Transplant Patients

  Transplantation and Cellular Therapy · 2017 · 10.1016/j.bbmt.2017.03.029

• A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool

  Chemical Communications · 2016 · 10.1039/c6cc03244c

• Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective

  Drug Discovery Today · 2015 · 10.1016/j.drudis.2015.09.009

• Engineering aldolases as biocatalysts

  Current Opinion in Chemical Biology · 2014 · 10.1016/j.cbpa.2013.12.010

• High-Content, High-Throughput Screening for the Identification of Cytotoxic Compounds Based on Cell Morphology and Cell Proliferation Markers

  PLoS ONE · 2014 · 10.1371/journal.pone.0088338

• A unified lead-oriented synthesis of over fifty molecular scaffolds

  Organic & Biomolecular Chemistry · 2014 · 10.1039/c4ob02287d

• Recent advances and applications of iridium-catalysed asymmetric allylic substitution

  Organic & Biomolecular Chemistry · 2012 · 10.1039/c2ob07086c

• A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3

  Journal of Cell Science · 2011 · 10.1242/jcs.081679

• Synthesis of Natural‐Product‐Like Molecules with Over Eighty Distinct Scaffolds

  Angewandte Chemie International Edition · 2008 · 10.1002/anie.200804486

• Convergent, Regiospecific Synthesis of Quinolines from o-Aminophenylboronates

  Organic Letters · 2008 · 10.1021/ol8016726

• Directed evolution of aldolases for exploitation in synthetic organic chemistry

  Archives of Biochemistry and Biophysics · 2008 · 10.1016/j.abb.2008.01.005

• Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries

  Natural Product Reports · 2008 · 10.1039/b706296f

• Regulation of Nanog Expression by Phosphoinositide 3-Kinase-dependent Signaling in Murine Embryonic Stem Cells

  Journal of Biological Chemistry · 2007 · 10.1074/jbc.m610906200

• D-KEFS Trail Making Test performance in patients with lateral prefrontal cortex lesions

  Journal of the International Neuropsychological Society · 2007 · 10.1017/s1355617707070907

• Multiple Cognitive Deficits in Amnestic Mild Cognitive Impairment

  Dementia and Geriatric Cognitive Disorders · 2006 · 10.1159/000095303

• Structural Basis of Inhibitor Specificity of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM-1) Kinase

  Journal of Medicinal Chemistry · 2005 · 10.1021/jm0504858

• Towards phase-transfer catalysts with a chiral anion: inducing asymmetry in the reactions of cations

  Tetrahedron Asymmetry · 2003 · 10.1016/s0957-4166(03)00367-7

• Modifying the stereochemistry of an enzyme-catalyzed reaction by directed evolution

  Proceedings of the National Academy of Sciences · 2003 · 10.1073/pnas.0635924100

• Asymmetric Phase-Transfer Catalysis

  Angewandte Chemie International Edition · 1999 · 10.1002/(sici)1521-3773(19990601)38:11<1583::aid-anie1583>3.0.co;2-e

Current projects

No projects listed.