Jörn Lötsch

Research interests

Publications

• Machine learning in pain research

  Pain · 2017 · 10.1097/j.pain.0000000000001118

• Chronic opioid use is associated with increased DNA methylation correlating with increased clinical pain

  Pain · 2012 · 10.1016/j.pain.2012.06.011

• Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients

  Journal of Hepatology · 2010 · 10.1016/j.jhep.2010.07.041

• Ziconotide for treatment of severe chronic pain

  The Lancet · 2010 · https://doi.org/10.1016/s0140-6736(10)60354-6

• Meta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatment

  Pain · 2009 · 10.1016/j.pain.2009.07.013

• Ceramide synthases and ceramide levels are increased in breast cancer tissue

  Carcinogenesis · 2009 · 10.1093/carcin/bgp061

• A Common Human μ-Opioid Receptor Genetic Variant Diminishes the Receptor Signaling Efficacy in Brain Regions Processing the Sensory Information of Pain

  Journal of Biological Chemistry · 2008 · 10.1074/jbc.m807030200

• Different Odor Tests Contribute Differently to the Evaluation of Olfactory Loss

  Chemical Senses · 2007 · 10.1093/chemse/bjm058

• Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication

  The Pharmacogenomics Journal · 2006 · https://doi.org/10.1038/sj.tpj.6500406

• Clinical Significance of Results from Olfactory Testing

  The Laryngoscope · 2006 · 10.1097/01.mlg.0000234915.51189.cb

• GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence

  Nature Medicine · 2006 · https://doi.org/10.1038/nm1490

• The μ-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers

  Pharmacogenetics and Genomics · 2006 · 10.1097/01.fpc.0000220566.90466.a2

• Pharmacokinetic–Pharmacodynamic Modeling of Opioids

  Journal of Pain and Symptom Management · 2005 · 10.1016/j.jpainsymman.2005.01.012

• Analgesic effects of morphine and morphine‐6‐glucuronide in a transcutaneous electrical pain model in healthy volunteers

  Clinical Pharmacology & Therapeutics · 2003 · 10.1067/mcp.2003.5

• Olfactory Function in Mild Cognitive Impairment and Alzheimer’s Disease: An Investigation Using Psychophysical and Electrophysiological Techniques

  American Journal of Psychiatry · 2003 · 10.1176/appi.ajp.160.11.1995

• The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine

  Pharmacogenetics · 2002 · 10.1097/00008571-200201000-00002

• Does the A118G Polymorphism at the μ-opioid Receptor Gene Protect against Morphine-6-Glucuronide Toxicity?

  Anesthesiology · 2002 · 10.1097/00000542-200210000-00011

Current projects

No projects listed.