Toni T. Seppälä

Research interests

Publications

• Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database

  EClinicalMedicine · 2023 · 10.1016/j.eclinm.2023.101909

• Lynch Syndrome Genetics and Clinical Implications

  Gastroenterology · 2023 · 10.1053/j.gastro.2022.08.058

• Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines

  Clinical Gastroenterology and Hepatology · 2022 · 10.1016/j.cgh.2022.12.006

• Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease–Associated Colorectal Cancer

  Gastroenterology · 2021 · https://doi.org/10.1053/j.gastro.2021.04.042

• European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

  British journal of surgery · 2020 · https://doi.org/10.1002/bjs.11902

• Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial

  The Lancet · 2020 · https://doi.org/10.1016/s0140-6736(20)30366-4

• The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-18514-5

• Incidence and management of patients with colorectal cancer and synchronous and metachronous colorectal metastases: a population-based study

  BJS Open · 2020 · 10.1002/bjs5.50299

• Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer

  Annals of Surgery · 2020 · 10.1097/sla.0000000000004200

• Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

  Genetics in Medicine · 2019 · https://doi.org/10.1038/s41436-019-0596-9

• No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies

  Gastroenterology · 2018 · https://doi.org/10.1053/j.gastro.2018.07.030

• Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

  Gut · 2017 · https://doi.org/10.1136/gutjnl-2017-314057

• Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database

  Gut · 2016 · https://doi.org/10.1136/gutjnl-2016-311403

• Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database

  Gut · 2015 · https://doi.org/10.1136/gutjnl-2015-309675

• Combination of microsatellite instability and BRAF mutation status for subtyping colorectal cancer

  British Journal of Cancer · 2015 · 10.1038/bjc.2015.160

• CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings

  Neurology · 2012 · 10.1212/wnl.0b013e3182563bd0

• National learning curve for laparoscopic hysterectomy and trends in hysterectomy in Finland 2000-2005

  Human Reproduction · 2008 · 10.1093/humrep/den006

• Increased Premature Mortality of Competitive Powerlifters Suspected to Have Used Anabolic Agents

  International Journal of Sports Medicine · 2000 · 10.1055/s-2000-304

• Comparison of analgesic efficacy of oxycodone and morphine in postoperative intravenous patient‐controlled analgesia

  Acta Anaesthesiologica Scandinavica · 1998 · 10.1111/j.1399-6576.1998.tb05169.x

• The pharmacokinetics and metabolism of oxycodone after intramuscular and oral administration to healthy subjects.

  British Journal of Clinical Pharmacology · 1992 · https://doi.org/10.1111/j.1365-2125.1992.tb04090.x

• The pharmacokinetics of oxycodone after intravenous injection in adults.

  British Journal of Clinical Pharmacology · 1991 · 10.1111/j.1365-2125.1991.tb03942.x

• [Aneurysm of the pulmonary artery].

  PubMed · 1956

Current projects

No projects listed.