Peppi Koivunen

Research interests

Publications

• 2-Oxoglutarate-dependent dioxygenases in cancer

  Nature reviews. Cancer · 2020 · https://doi.org/10.1038/s41568-020-00303-3

• PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-13889-6

• Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

  Science · 2019 · https://doi.org/10.1126/science.aaw1026

• Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.05.042

• Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

  Journal of Biological Chemistry · 2015 · https://doi.org/10.1074/jbc.m115.688762

• A genetic mechanism for Tibetan high-altitude adaptation

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.3067

• ( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

  Science · 2013 · https://doi.org/10.1126/science.1231677

• Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

  Nature · 2012 · https://doi.org/10.1038/nature10898

• Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates

  Journal of Biological Chemistry · 2006 · https://doi.org/10.1074/jbc.m610415200

• Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway

  The FASEB Journal · 2005 · https://doi.org/10.1096/fj.04-3399fje

• Catalytic Properties of the Asparaginyl Hydroxylase (FIH) in the Oxygen Sensing Pathway Are Distinct from Those of Its Prolyl 4-Hydroxylases

  Journal of Biological Chemistry · 2004 · https://doi.org/10.1074/jbc.m312254200

• Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor

  Journal of Biological Chemistry · 2003 · https://doi.org/10.1074/jbc.m304982200

Current projects

No projects listed.