Wim Van Hul

Research interests

Publications

• PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

  Journal of Hepatology · 2015 · https://doi.org/10.1016/j.jhep.2015.02.019

• A look behind the scenes: the risk and pathogenesis of primary osteoporosis

  Nature Reviews Rheumatology · 2015 · https://doi.org/10.1038/nrrheum.2015.48

• Wnt Signaling and the Control of Human Stem Cell Fate

  Stem Cell Reviews and Reports · 2013 · 10.1007/s12015-013-9486-8

• Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

  Nature · 2012 · https://doi.org/10.1038/nature10798

• Bone Overgrowth-associated Mutations in the LRP4 Gene Impair Sclerostin Facilitator Function

  Journal of Biological Chemistry · 2011 · https://doi.org/10.1074/jbc.m110.190330

• TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

  Nature Medicine · 2009 · https://doi.org/10.1038/nm.1979

• Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans

  Journal of Clinical Investigation · 2007 · https://doi.org/10.1172/jci30328

• Reduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling

  Molecular and Cellular Biology · 2005 · https://doi.org/10.1128/mcb.25.12.4946-4955.2005

• Camurati-Engelmann disease: review of the clinical, radiological, and molecular data of 24 families and implications for diagnosis and treatment

  Journal of Medical Genetics · 2005 · https://doi.org/10.1136/jmg.2005.033522

• Transforming Growth Factor-β1 to the Bone

  Endocrine Reviews · 2005 · https://doi.org/10.1210/er.2004-0001

• Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis

  Nature Genetics · 2004 · https://doi.org/10.1038/ng1453

• LRP5 and Wnt Signaling: A Union Made for Bone

  Journal of Bone and Mineral Research · 2004 · https://doi.org/10.1359/jbmr.040816

• Six Novel Missense Mutations in the LDL Receptor-Related Protein 5 (LRP5) Gene in Different Conditions with an Increased Bone Density

  The American Journal of Human Genetics · 2003 · https://doi.org/10.1086/368277

• Extracellular Regulation of BMP Signaling in Vertebrates: A Cocktail of Modulators

  Developmental Biology · 2002 · https://doi.org/10.1006/dbio.2002.0779

• LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

  Cell · 2001 · https://doi.org/10.1016/s0092-8674(01)00571-2

• Mutations in the gene encoding the latency-associated peptide of TGF-β1 cause Camurati-Engelmann disease

  Nature Genetics · 2000 · https://doi.org/10.1038/81563

• Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis

  Nature Genetics · 2000 · https://doi.org/10.1038/71667

• Molecular basis of multiple exostoses: mutations in the EXT1 and EXT2 genes

  Human Mutation · 2000 · https://doi.org/10.1002/(sici)1098-1004(200003)15:3<220::aid-humu2>3.0.co;2-k

• Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia

  Nature Genetics · 1999 · https://doi.org/10.1038/12699

• Mutations in the EXT1 and EXT2 Genes in Hereditary Multiple Exostoses

  The American Journal of Human Genetics · 1998 · https://doi.org/10.1086/301726

• The peripheral myelin protein gene PMP–22 is contained within the Charcot–Marie–Tooth disease type 1A duplication

  Nature Genetics · 1992 · https://doi.org/10.1038/ng0692-171

• Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene

  Nature Genetics · 1992 · https://doi.org/10.1038/ng0692-218

• Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)

  Science · 1990 · https://doi.org/10.1126/science.1971458

• Germline mosaicism and Duchenne muscular dystrophy mutations

  Nature · 1987 · 10.1038/329554a0

• Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families

  Nature · 1987 · https://doi.org/10.1038/329153a0

Current projects

No projects listed.