Hilde Lavreysen

Research interests

Publications

• Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor

  Structure · 2017 · 10.1016/j.str.2017.05.021

• Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM)

  Journal of Medicinal Chemistry · 2016 · 10.1021/acs.jmedchem.6b00913

• Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ‐46281222

  British Journal of Pharmacology · 2015 · 10.1111/bph.13390

• Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia

  ACS Medicinal Chemistry Letters · 2015 · 10.1021/acsmedchemlett.5b00181

• Preclinical evaluation of the antipsychotic potential of the mGlu2‐positive allosteric modulator JNJ‐40411813

  Pharmacology Research & Perspectives · 2015 · 10.1002/prp2.97

• Biased mGlu 5 -Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu 5 Modulation of NMDAR Currents

  Neuron · 2015 · 10.1016/j.neuron.2015.03.063

• Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1 H )-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

  Journal of Medicinal Chemistry · 2014 · 10.1021/jm500496m

• Pharmacological and pharmacokinetic properties of JNJ‐40411813, a positive allosteric modulator of the mGlu2 receptor

  Pharmacology Research & Perspectives · 2014 · 10.1002/prp2.96

• Pharmacological Characterization of JNJ-40068782, a New Potent, Selective, and Systemically Active Positive Allosteric Modulator of the mGlu2 Receptor and Its Radioligand [3H]JNJ-40068782

  Journal of Pharmacology and Experimental Therapeutics · 2013 · 10.1124/jpet.113.204990

• N-Aryl Piperazine Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators Possess Efficacy in Preclinical Models of NMDA Hypofunction and Cognitive Enhancement

  Journal of Pharmacology and Experimental Therapeutics · 2013 · 10.1124/jpet.113.206623

• Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging

  Journal of Medicinal Chemistry · 2012 · 10.1021/jm300912k

• Pharmacology of JNJ-37822681, a Specific and Fast-Dissociating D2 Antagonist for the Treatment of Schizophrenia

  Journal of Pharmacology and Experimental Therapeutics · 2012 · 10.1124/jpet.111.190702

• Discovery of 3-Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

  Journal of Medicinal Chemistry · 2012 · 10.1021/jm3010724

• Imidazo[1,2-a]pyridines: Orally Active Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

  Journal of Medicinal Chemistry · 2012 · 10.1021/jm201561r

• Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

  Molecular Pharmacology · 2011 · 10.1124/mol.111.075184

• Acetylcholinesterase and Cognitive Enhancement

  Journal · 2010 · 10.1007/978-3-540-68706-1_164

• Summary of Product Characteristics

  Journal · 2010 · 10.1007/978-3-540-68706-1_698

• Summary of Product Characteristics

  Journal · 2010 · 10.1007/978-3-540-68706-1_698

• Characterization of 2-[[4-Fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor

  Journal of Pharmacology and Experimental Therapeutics · 2010 · 10.1124/jpet.110.173245

• Addiction Research Center Inventory

  Journal · 2010 · 10.1007/978-3-540-68706-1_938

• Attention Deficit and Disruptive Behavior Disorders

  Journal · 2010 · 10.1007/978-3-540-68706-1_338

• Attention Deficit and Disruptive Behavior Disorders

  Journal · 2010 · 10.1007/978-3-540-68706-1_338

• Attention Deficit Hyperactivity Disorder

  Journal · 2010 · 10.1007/978-3-540-68706-1_488

• Attention Deficit Hyperactivity Disorder

  Journal · 2010 · 10.1007/978-3-540-68706-1_488

• Acetylcholinesterase and Cognitive Enhancement

  Journal · 2010 · 10.1007/978-3-540-68706-1_164

• Progress in the Developement of Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2

  Current Medicinal Chemistry · 2010 · 10.2174/092986711793979706

• Metabotropic Glutamate Receptors: Their Therapeutic Potential in Anxiety

  Current topics in behavioral neurosciences · 2010 · 10.1007/7854_2010_36

• Signal Detection Theory

  Journal · 2010 · 10.1007/978-3-540-68706-1_848

• Somatostatin Receptors

  Journal · 2010 · 10.1007/978-3-540-68706-1_1633

• Single Photon Emission Computed Tomography

  Journal · 2010 · 10.1007/978-3-540-68706-1_3573

• Refractory Schizophrenia

  Journal · 2010 · 10.1007/978-3-540-68706-1_4504

• Alcohol Withdrawal Syndrome

  Journal · 2010 · 10.1007/978-3-540-68706-1_448

• Alcohol Withdrawal Syndrome

  Journal · 2010 · 10.1007/978-3-540-68706-1_448

• Receptors: Binding Assays

  Journal · 2010 · 10.1007/978-3-540-68706-1_207

• Reactive Oxygen Species

  Journal · 2010 · 10.1007/978-3-540-68706-1_1391

• Activities of Daily Living

  Journal · 2010 · 10.1007/978-3-540-68706-1_1173

• Activities of Daily Living

  Journal · 2010 · 10.1007/978-3-540-68706-1_1173

• Atypical Antipsychotic Drugs

  Journal · 2010 · 10.1007/978-3-540-68706-1_468

• Atypical Antipsychotic Drugs

  Journal · 2010 · 10.1007/978-3-540-68706-1_468

• Addiction Research Center Inventory

  Journal · 2010 · 10.1007/978-3-540-68706-1_938

• Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor

  Bioorganic & Medicinal Chemistry Letters · 2009 · 10.1016/j.bmcl.2009.11.008

• Therapeutic Potential of Group III Metabotropic Glutamate Receptors

  Current Medicinal Chemistry · 2008 · 10.2174/092986708783885246

• Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative autoradiographic study using [3H]R214127

  Neuropharmacology · 2004 · 10.1016/j.neuropharm.2003.11.014

• Effects of mGlu1 receptor blockade on anxiety-related behaviour in the rat lick suppression test

  Psychopharmacology · 2004 · 10.1007/s00213-004-2056-7

• JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist

  Neuropharmacology · 2004 · 10.1016/j.neuropharm.2004.08.007

• [3H]R214127: A Novel High-Affinity Radioligand for the mGlu1 Receptor Reveals a Common Binding Site Shared by Multiple Allosteric Antagonists

  Molecular Pharmacology · 2003 · 10.1124/mol.63.5.1082

Current projects

No projects listed.