Piet Herdewijn

Research interests

Publications

• Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

  Journal of Clinical Investigation · 2017 · 10.1172/jci89857

• Catalysts from synthetic genetic polymers

  Nature · 2014 · 10.1038/nature13982

• Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

  Journal of Antimicrobial Chemotherapy · 2014 · 10.1093/jac/dku209

• Synthetic Genetic Polymers Capable of Heredity and Evolution

  Science · 2012 · https://doi.org/10.1126/science.1217622

• Chemical Evolution of a Bacterium’s Genome

  Angewandte Chemie International Edition · 2011 · 10.1002/anie.201100535

• A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

  Nucleic Acids Research · 2010 · https://doi.org/10.1093/nar/gkq341

• Toward Safe Genetically Modified Organisms through the Chemical Diversification of Nucleic Acids

  Chemistry & Biodiversity · 2009 · 10.1002/cbdv.200900083

• A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

  Nucleic Acids Research · 2009 · https://doi.org/10.1093/nar/gkp106

• α- l -ribo-Configured Locked Nucleic Acid (α-L-LNA): Synthesis and Properties

  Journal of the American Chemical Society · 2002 · 10.1021/ja0168763

• Cyclohexene Nucleic Acids (CeNA): Serum Stable Oligonucleotides that Activate RNase H and Increase Duplex Stability with Complementary RNA

  Journal of the American Chemical Society · 2000 · 10.1021/ja000018+

• Modifications in Lignin and Accumulation of Phenolic Glucosides in Poplar Xylem upon Down-regulation of Caffeoyl-Coenzyme A O-Methyltransferase, an Enzyme Involved in Lignin Biosynthesis

  Journal of Biological Chemistry · 2000 · 10.1074/jbc.m006915200

• Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands

  Proteins Structure Function and Bioinformatics · 1998 · 10.1002/(sici)1097-0134(19980815)32:3<350::aid-prot10>3.0.co;2-8

• Characterization of Synthetic Human Granulocyte Chemotactic Protein 2: Usage of Chemokine Receptors CXCR1 and CXCR2 andin VivoInflammatory Properties

  Biochemistry · 1997 · 10.1021/bi961999z

• Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides

  Journal of Medicinal Chemistry · 1993 · 10.1021/jm00066a013

• Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound.

  Proceedings of the National Academy of Sciences · 1991 · 10.1073/pnas.88.4.1499

• Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.

  Proceedings of the National Academy of Sciences · 1989 · 10.1073/pnas.86.1.332

• Differential Patterns of Intracellular Metabolism of 2′,3′-Didehydro-2′,3′-dideoxythymidine and 3′-Azido-2′,3′-dideoxythymidine, Two Potent Anti-human Immunodeficiency Virus Compounds

  Journal of Biological Chemistry · 1989 · https://doi.org/10.1016/s0021-9258(18)83322-1

• Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

  Journal of Virological Methods · 1988 · https://doi.org/10.1016/0166-0934(88)90134-6

• Anti-retrovirus activity of 3′-fluoro- and 3′-azido-substituted pyrimidine 2′,3′-dideoxynucleoside analogues

  Biochemical Pharmacology · 1988 · 10.1016/0006-2952(88)90049-4

• The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3′-azido-2′,3′-dideoxythymidine and 2′,3′-dideoxycytidine are highly dependent on the cell species

  Biochemical Pharmacology · 1988 · 10.1016/0006-2952(88)90178-5

• Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro

  Antimicrobial Agents and Chemotherapy · 1987 · 10.1128/aac.31.10.1613

• Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus

  Journal of Virological Methods · 1987 · 10.1016/0166-0934(87)90002-4

• Both 2′,3′-dideoxythymidine and its 2′,3′-unsaturated derivative (2′,3′-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro

  Biochemical and Biophysical Research Communications · 1987 · https://doi.org/10.1016/0006-291x(87)90460-8

• 3'-Substituted 2',3'-dideoxynucleoside analogs as potential anti-HIV (HTLV-III/LAV) agents

  Journal of Medicinal Chemistry · 1987 · 10.1021/jm00391a003

• The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: a comparison with their parental 2',3'-dideoxyribonucleosides.

  Molecular Pharmacology · 1987 · 10.1016/s0026-895x(25)13752-8

Current projects

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