Patrick Augustijns

Research interests

Publications

• Local immune response to food antigens drives meal-induced abdominal pain

  Nature · 2021 · https://doi.org/10.1038/s41586-020-03118-2

• Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review

  European Journal of Pharmaceutical Sciences · 2021 · https://doi.org/10.1016/j.ejps.2021.105812

• Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity

  Proceedings of the National Academy of Sciences · 2020 · https://doi.org/10.1073/pnas.2014441117

• Impact of gastrointestinal physiology on drug absorption in special populations––An UNGAP review

  European Journal of Pharmaceutical Sciences · 2020 · https://doi.org/10.1016/j.ejps.2020.105280

• Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review

  European Journal of Pharmaceutical Sciences · 2019 · https://doi.org/10.1016/j.ejps.2019.04.013

• Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

  European Journal of Pharmaceutical Sciences · 2019 · https://doi.org/10.1016/j.ejps.2019.104967

• The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group

  European Journal of Pharmaceutical Sciences · 2019 · https://doi.org/10.1016/j.ejps.2019.04.003

• Histamine Receptor H1–Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

  Gastroenterology · 2016 · https://doi.org/10.1053/j.gastro.2015.12.034

• Microbiota-Derived Phenylacetylglutamine Associates with Overall Mortality and Cardiovascular Disease in Patients with CKD

  Journal of the American Society of Nephrology · 2016 · https://doi.org/10.1681/asn.2015121302

• In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

  European Journal of Pharmaceutical Sciences · 2014 · https://doi.org/10.1016/j.ejps.2014.02.010

• In vitro models for the prediction of in vivo performance of oral dosage forms

  European Journal of Pharmaceutical Sciences · 2013 · https://doi.org/10.1016/j.ejps.2013.08.024

• Supersaturating Drug Delivery Systems: The Answer to Solubility-Limited Oral Bioavailability?

  Journal of Pharmaceutical Sciences · 2009 · https://doi.org/10.1002/jps.21650

• Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

  European Journal of Pharmaceutical Sciences · 2008 · https://doi.org/10.1016/j.ejps.2008.08.004

• Top-down production of drug nanocrystals: Nanosuspension stabilization, miniaturization and transformation into solid products

  International Journal of Pharmaceutics · 2008 · https://doi.org/10.1016/j.ijpharm.2008.07.023

• Ordered Mesoporous Silica Material SBA-15: A Broad-Spectrum Formulation Platform for Poorly Soluble Drugs

  Journal of Pharmaceutical Sciences · 2008 · https://doi.org/10.1002/jps.21638

• Physical State of Poorly Water Soluble Therapeutic Molecules Loaded into SBA-15 Ordered Mesoporous Silica Carriers: A Case Study with Itraconazole and Ibuprofen

  Langmuir · 2008 · https://doi.org/10.1021/la801161g

• A screening study of surface stabilization during the production of drug nanocrystals

  Journal of Pharmaceutical Sciences · 2008 · https://doi.org/10.1002/jps.21563

• Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica

  European Journal of Pharmaceutics and Biopharmaceutics · 2007 · https://doi.org/10.1016/j.ejpb.2007.11.006

• Physical stabilisation of amorphous ketoconazole in solid dispersions with polyvinylpyrrolidone K25

  European Journal of Pharmaceutical Sciences · 2001 · https://doi.org/10.1016/s0928-0987(00)00173-1

Current projects

No projects listed.