Frank Speleman

Research interests

Publications

• A mechanistic classification of clinical phenotypes in neuroblastoma

  Science · 2018 · https://doi.org/10.1126/science.aat6768

• Mutational dynamics between primary and relapse neuroblastomas

  Nature Genetics · 2015 · 10.1038/ng.3349

• Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma

  Science Translational Medicine · 2015 · https://doi.org/10.1126/scitranslmed.aab1803

• Mutational dynamics between primary and relapse neuroblastomas

  Nature Genetics · 2015 · 10.1038/ng.3349

• Emergence of New ALK Mutations at Relapse of Neuroblastoma

  Journal of Clinical Oncology · 2014 · https://doi.org/10.1200/jco.2013.54.0674

• RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

  Nature · 2014 · 10.1038/nature13485

• RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

  Nature · 2014 · 10.1038/nature13485

• Comprehensive Analysis of Transcriptome Variation Uncovers Known and Novel Driver Events in T-Cell Acute Lymphoblastic Leukemia

  PLoS Genetics · 2013 · https://doi.org/10.1371/journal.pgen.1003997

• LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

  Nature Genetics · 2012 · 10.1038/ng.2436

• LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

  Nature Genetics · 2012 · 10.1038/ng.2436

• A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

  Nature Genetics · 2011 · https://doi.org/10.1038/ng.858

• Meta-analysis of Neuroblastomas Reveals a Skewed ALK Mutation Spectrum in Tumors with MYCN Amplification

  Clinical Cancer Research · 2010 · https://doi.org/10.1158/1078-0432.ccr-09-2660

• PHF6 mutations in adult acute myeloid leukemia

  Leukemia · 2010 · https://doi.org/10.1038/leu.2010.247

• miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

  Nature Cell Biology · 2010 · 10.1038/ncb2024

• PHF6 mutations in T-cell acute lymphoblastic leukemia

  Nature Genetics · 2010 · 10.1038/ng.542

• The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma

  Molecular Cell · 2010 · 10.1016/j.molcel.2010.11.038

• miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

  Nature Cell Biology · 2010 · 10.1038/ncb2024

• PHF6 mutations in T-cell acute lymphoblastic leukemia

  Nature Genetics · 2010 · 10.1038/ng.542

• The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma

  Molecular Cell · 2010 · 10.1016/j.molcel.2010.11.038

• Overall Genomic Pattern Is a Predictor of Outcome in Neuroblastoma

  Journal of Clinical Oncology · 2009 · https://doi.org/10.1200/jco.2008.16.0630

• A novel and universal method for microRNA RT-qPCR data normalization

  Genome biology · 2009 · 10.1186/gb-2009-10-6-r64

• International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee

  British Journal of Cancer · 2009 · https://doi.org/10.1038/sj.bjc.6605014

• Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study

  The Lancet Oncology · 2009 · https://doi.org/10.1016/s1470-2045(09)70154-8

• Further delineation of the 15q13 microdeletion and duplication syndromes: a clinical spectrum varying from non-pathogenic to a severe outcome

  Journal of Medical Genetics · 2009 · https://doi.org/10.1136/jmg.2008.063412

• A novel and universal method for microRNA RT-qPCR data normalization

  Genome biology · 2009 · 10.1186/gb-2009-10-6-r64

• Identification of ALK as a major familial neuroblastoma predisposition gene

  Nature · 2008 · 10.1038/nature07261

• High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA

  Nucleic Acids Research · 2008 · 10.1093/nar/gkn725

• Identification of ALK as a major familial neuroblastoma predisposition gene

  Nature · 2008 · 10.1038/nature07261

• High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA

  Nucleic Acids Research · 2008 · 10.1093/nar/gkn725

• Recurrent Rearrangements of Chromosome 1q21.1 and Variable Pediatric Phenotypes

  New England Journal of Medicine · 2008 · https://doi.org/10.1056/nejmoa0805384

• qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data

  Genome biology · 2007 · 10.1186/gb-2007-8-2-r19

• Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

  Nature Genetics · 2007 · https://doi.org/10.1038/ng2025

• qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data

  Genome biology · 2007 · 10.1186/gb-2007-8-2-r19

• Unequivocal Delineation of Clinicogenetic Subgroups and Development of a New Model for Improved Outcome Prediction in Neuroblastoma

  Journal of Clinical Oncology · 2005 · https://doi.org/10.1200/jco.2005.06.104

• Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis

  Nature Genetics · 2004 · https://doi.org/10.1038/ng1453

• Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome

  Nature Genetics · 2003 · 10.1038/ng1122

• Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome

  Nature Genetics · 2003 · 10.1038/ng1122

• ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma

  Blood · 2003 · https://doi.org/10.1182/blood-2003-04-1050

• Elimination of Primer–Dimer Artifacts and Genomic Coamplification Using a Two-Step SYBR Green I Real-Time RT-PCR

  Analytical Biochemistry · 2002 · 10.1006/abio.2001.5564

• Elimination of Primer–Dimer Artifacts and Genomic Coamplification Using a Two-Step SYBR Green I Real-Time RT-PCR

  Analytical Biochemistry · 2002 · 10.1006/abio.2001.5564

• Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein–methyltransferase superfamily

  Genes & Development · 2001 · 10.1101/gad.870101

• Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein–methyltransferase superfamily

  Genes & Development · 2001 · 10.1101/gad.870101

• Exhaustive mutation analysis of theNF1 gene allows identification of 95% of mutations and reveals a high frequency of unusual splicing defects

  Human Mutation · 2000 · https://doi.org/10.1002/1098-1004(200006)15:6<541::aid-humu6>3.0.co;2-n

• EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts

  Nature Genetics · 1993 · 10.1038/ng0893-341

• EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts

  Nature Genetics · 1993 · 10.1038/ng0893-341

Current projects

No projects listed.