Zeger Debyser

Research interests

Publications

• Block-And-Lock Strategies to Cure HIV Infection

  Viruses · 2020 · https://doi.org/10.3390/v12010084

• The BET Family of Proteins Targets Moloney Murine Leukemia Virus Integration near Transcription Start Sites

  Cell Reports · 2013 · https://doi.org/10.1016/j.celrep.2013.09.040

• Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization

  Antimicrobial Agents and Chemotherapy · 2012 · https://doi.org/10.1128/aac.00717-12

• Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

  Journal of Cell Science · 2011 · https://doi.org/10.1242/jcs.078303

• Rapid, Simple, and Versatile Manufacturing of Recombinant Adeno-Associated Viral Vectors at Scale

  Human Gene Therapy · 2010 · https://doi.org/10.1089/hum.2010.055

• Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

  Nature Chemical Biology · 2010 · https://doi.org/10.1038/nchembio.370

• Transportin-SR2 Imports HIV into the Nucleus

  Current Biology · 2008 · https://doi.org/10.1016/j.cub.2008.07.079

• Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure−Activity Relationship of a Class of Human Immunodeficiency Virus type 1 Integrase Inhibitors

  Journal of Medicinal Chemistry · 2008 · https://doi.org/10.1021/jm8003784

• Comparative Analysis of Adeno-Associated Viral Vector Serotypes 1, 2, 5, 7, And 8 in Mouse Brain

  Human Gene Therapy · 2007 · https://doi.org/10.1089/hum.2006.178

• Comparison of lentiviral vector titration methods

  BMC Biotechnology · 2006 · https://doi.org/10.1186/1472-6750-6-34

• Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency Virus

  Journal of Virology · 2006 · https://doi.org/10.1128/jvi.80.4.1886-1896.2006

• Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus Replication

  Journal of Virology · 2006 · https://doi.org/10.1128/jvi.00801-06

• Cellular co-factors of HIV-1 integration

  Trends in Biochemical Sciences · 2006 · https://doi.org/10.1016/j.tibs.2005.12.002

• Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impairedin Chromosome Tethering and HIV-1Replication

  Journal of Biological Chemistry · 2005 · https://doi.org/10.1074/jbc.m501378200

• The Interaction of LEDGF/p75 with Integrase Is Lentivirus-specific and Promotes DNA Binding

  Journal of Biological Chemistry · 2005 · https://doi.org/10.1074/jbc.m411681200

• LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells

  Journal of Biological Chemistry · 2003 · https://doi.org/10.1074/jbc.m303594200

• HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells

  Journal of Biological Chemistry · 2002 · https://doi.org/10.1074/jbc.m209278200

• Polyanionic (i.e., Polysulfonate) Dendrimers Can Inhibit the Replication of Human Immunodeficiency Virus by Interfering with Both Virus Adsorption and Later Steps (Reverse Transcriptase/Integrase) in the Virus Replicative Cycle

  Molecular Pharmacology · 2000 · 10.1124/mol.58.5.1100

• Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

  Antimicrobial Agents and Chemotherapy · 1994 · https://doi.org/10.1128/aac.38.4.668

• Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.

  Proceedings of the National Academy of Sciences · 1993 · https://doi.org/10.1073/pnas.90.5.1711

• Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.

  Proceedings of the National Academy of Sciences · 1992 · https://doi.org/10.1073/pnas.89.12.5286

• An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives.

  Proceedings of the National Academy of Sciences · 1991 · https://doi.org/10.1073/pnas.88.4.1451

Current projects

No projects listed.