Christophe Pannecouque

Research interests

Publications

• Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses

  Chemical Society Reviews · 2021 · 10.1039/d0cs01084g

• Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years

  Acta Pharmaceutica Sinica B · 2019 · 10.1016/j.apsb.2019.11.010

• Overview of Recent Strategic Advances in Medicinal Chemistry

  Journal of Medicinal Chemistry · 2019 · 10.1021/acs.jmedchem.9b00359

• Graphene Quantum Dots Based Systems As HIV Inhibitors

  Bioconjugate Chemistry · 2018 · 10.1021/acs.bioconjchem.8b00448

• Bioactive Natural Products Prioritization Using Massive Multi-informational Molecular Networks

  ACS Chemical Biology · 2017 · 10.1021/acschembio.7b00413

• Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles

  Journal of Medicinal Chemistry · 2016 · 10.1021/acs.jmedchem.6b00738

• Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity

  Journal of Medicinal Chemistry · 2015 · 10.1021/acs.jmedchem.5b01183

• Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

  Journal of Medicinal Chemistry · 2015 · https://doi.org/10.1021/acs.jmedchem.5b00497

• Anti-HIV-1 activity of the G-quadruplex ligand BRACO-19

  Journal of Antimicrobial Chemotherapy · 2014 · 10.1093/jac/dku280

• Indolylarylsulfones as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: New Cyclic Substituents at Indole-2-carboxamide

  Journal of Medicinal Chemistry · 2011 · 10.1021/jm101614j

• A time-of–drug addition approach to target identification of antiviral compounds

  Nature Protocols · 2011 · 10.1038/nprot.2011.330

• A 1,8-Naphthyridone Derivative Targets the HIV-1 Tat-Mediated Transcription and Potently Inhibits the HIV-1 Replication

  Journal of Medicinal Chemistry · 2009 · 10.1021/jm901211d

• Synthesis and antiviral activity of new pyrazole and thiazole derivatives

  European Journal of Medicinal Chemistry · 2009 · https://doi.org/10.1016/j.ejmech.2009.03.038

• Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

  Nature Protocols · 2008 · 10.1038/nprot.2007.517

• Improved and rapid synthesis of new coumarinyl chalcone derivatives and their antiviral activity

  Tetrahedron Letters · 2007 · 10.1016/j.tetlet.2007.09.175

• Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents

  Bioorganic & Medicinal Chemistry · 2007 · 10.1016/j.bmc.2007.02.044

• Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle

  Antiviral Research · 2007 · 10.1016/j.antiviral.2007.03.003

• Design, synthesis, and evaluation of 2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents

  Bioorganic & Medicinal Chemistry · 2006 · 10.1016/j.bmc.2006.12.003

• Susceptibility of HIV-2, Siv and Shiv to Various Anti-HIV-1 Compounds: Implications for Treatment and Postexposure Prophylaxis

  Antiviral Therapy · 2004 · 10.1177/135965350400900115

• Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles

  Il Farmaco · 2002 · 10.1016/s0014-827x(01)01189-2

• Design, Synthesis, Structure−Activity Relationships, and Molecular Modeling Studies of 2,3-Diaryl-1,3-thiazolidin-4-ones as Potent Anti-HIV Agents

  Journal of Medicinal Chemistry · 2002 · 10.1021/jm020977+

• Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents

  Bioorganic & Medicinal Chemistry Letters · 2001 · 10.1016/s0960-894x(01)00304-3

• Antiviral activity against human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) of ethnobotanically selected Ethiopian medicinal plants

  Phytotherapy Research · 2001 · 10.1002/1099-1573(200102)15:1<62::aid-ptr956>3.0.co;2-x

• Polyanionic (i.e., Polysulfonate) Dendrimers Can Inhibit the Replication of Human Immunodeficiency Virus by Interfering with Both Virus Adsorption and Later Steps (Reverse Transcriptase/Integrase) in the Virus Replicative Cycle

  Molecular Pharmacology · 2000 · 10.1124/mol.58.5.1100

• Chicoric Acid Analogues as HIV-1 Integrase Inhibitors

  Journal of Medicinal Chemistry · 1999 · 10.1021/jm980531m

Current projects

No projects listed.