Johannes V. Swinnen

Research interests

Publications

• Lipid metabolism in cancer: New perspectives and emerging mechanisms

  Developmental Cell · 2021 · 10.1016/j.devcel.2021.04.013

• Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

  Advanced Drug Delivery Reviews · 2020 · https://doi.org/10.1016/j.addr.2020.07.013

• ATP13A2 deficiency disrupts lysosomal polyamine export

  Nature · 2020 · 10.1038/s41586-020-1968-7

• Lipid metabolism in cancer cells under metabolic stress

  British Journal of Cancer · 2019 · 10.1038/s41416-019-0451-4

• Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

  Nature · 2019 · https://doi.org/10.1038/s41586-019-0904-1

• Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

  Cell Metabolism · 2018 · 10.1016/j.cmet.2018.07.019

• EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

  Nature Methods · 2017 · 10.1038/nmeth.4185

• CRISP-ID: decoding CRISPR mediated indels by Sanger sequencing

  Scientific Reports · 2016 · 10.1038/srep28973

• Non‐small cell lung cancer is characterized by dramatic changes in phospholipid profiles

  International Journal of Cancer · 2015 · https://doi.org/10.1002/ijc.29517

• Lipogenesis and lipolysis: The pathways exploited by the cancer cells to acquire fatty acids

  Progress in Lipid Research · 2013 · 10.1016/j.plipres.2013.08.005

• ATP-Citrate Lyase: A Key Player in Cancer Metabolism

  Cancer Research · 2012 · 10.1158/0008-5472.can-11-4112

• Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation

  Molecular Cancer Therapeutics · 2011 · 10.1158/1535-7163.mct-10-0802

• De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

  Cancer Research · 2010 · 10.1158/0008-5472.can-09-3871

• Chemical Inhibition of Acetyl-CoA Carboxylase Induces Growth Arrest and Cytotoxicity Selectively in Cancer Cells

  Cancer Research · 2007 · 10.1158/0008-5472.can-07-0389

• Increased lipogenesis in cancer cells: new players, novel targets

  Current Opinion in Clinical Nutrition & Metabolic Care · 2006 · 10.1097/01.mco.0000232894.28674.30

• Relative Impact of Androgen and Estrogen Receptor Activation in the Effects of Androgens on Trabecular and Cortical Bone in Growing Male Mice: A Study in the Androgen Receptor Knockout Mouse Model

  Journal of Bone and Mineral Research · 2006 · https://doi.org/10.1359/jbmr.060103

• RNA Interference–Mediated Silencing of the Acetyl-CoA-Carboxylase-α Gene Induces Growth Inhibition and Apoptosis of Prostate Cancer Cells

  Cancer Research · 2005 · 10.1158/0008-5472.can-05-0571

• Induction of Cancer Cell Apoptosis by Flavonoids Is Associated with Their Ability to Inhibit Fatty Acid Synthase Activity

  Journal of Biological Chemistry · 2004 · 10.1074/jbc.m408177200

• A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis

  Proceedings of the National Academy of Sciences · 2004 · 10.1073/pnas.0308114100

• Contribution of Circulating Lipids to the Improved Outcome of Critical Illness by Glycemic Control with Intensive Insulin Therapy

  The Journal of Clinical Endocrinology & Metabolism · 2004 · 10.1210/jc.2003-030760

• Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains

  Biochemical and Biophysical Research Communications · 2003 · 10.1016/s0006-291x(03)00265-1

• RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells.

  PubMed · 2003

• Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer

  International Journal of Cancer · 2001 · 10.1002/ijc.10127

• Selective activation of the fatty acid synthesis pathway in human prostate cancer

  International Journal of Cancer · 2000 · 10.1002/1097-0215(20001015)88:2<176::aid-ijc5>3.0.co;2-3

• Coordinate regulation of lipogenic gene expression by androgens: Evidence for a cascade mechanism involving sterol regulatory element binding proteins

  Proceedings of the National Academy of Sciences · 1997 · 10.1073/pnas.94.24.12975

Current projects

No projects listed.