Alexander Roller

Research interests

Publications

• Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux

  Journal of Medicinal Chemistry · 2020 · 10.1021/acs.jmedchem.0c01277

• Improving the Stability of Maleimide–Thiol Conjugation for Drug Targeting

  Chemistry - A European Journal · 2020 · 10.1002/chem.202003951

• A Highly Active PN 3 Manganese Pincer Complex Performing N-Alkylation of Amines under Mild Conditions

  Organic Letters · 2019 · 10.1021/acs.orglett.9b00832

• A Dogma in Doubt: Hydrolysis of Equatorial Ligands of Pt IV Complexes under Physiological Conditions

  Angewandte Chemie International Edition · 2019 · 10.1002/anie.201900682

• Telescoped, Divergent, Chemoselective C1 and C1‐C1 Homologation of Imine Surrogates: Access to Quaternary Chloro‐ and Halomethyl‐Trifluoromethyl Aziridines

  Angewandte Chemie International Edition · 2018 · 10.1002/anie.201812525

• Towards targeting anticancer drugs: ruthenium( ii )–arene complexes with biologically active naphthoquinone-derived ligand systems

  Dalton Transactions · 2016 · 10.1039/c6dt01110a

• An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo

  Chemical Science · 2016 · 10.1039/c6sc03862j

• Task-specific thioglycolate ionic liquids for heavy metal extraction: Synthesis, extraction efficacies and recycling properties

  Journal of Hazardous Materials · 2016 · 10.1016/j.jhazmat.2016.10.054

• Iron(II) Complexes Containing Chiral Unsymmetrical PNP′ Pincer Ligands: Synthesis and Application in Asymmetric Hydrogenations

  Organometallics · 2016 · 10.1021/acs.organomet.6b00711

• Introducing the 4-Phenyl-1,2,3-Triazole Moiety as a Versatile Scaffold for the Development of Cytotoxic Ruthenium(II) and Osmium(II) Arene Cyclometalates

  Inorganic Chemistry · 2016 · 10.1021/acs.inorgchem.6b02430

• Another step toward DNA selective targeting: Ni II and Cu II complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes

  Dalton Transactions · 2016 · 10.1039/c6dt00648e

• Half‐Sandwich Ruthenium(II) Biotin Conjugates as Biological Vectors to Cancer Cells

  Chemistry - A European Journal · 2015 · 10.1002/chem.201403974

• Half‐Sandwich Ruthenium(II) Biotin Conjugates as Biological Vectors to Cancer Cells

  Chemistry - A European Journal · 2015 · 10.1002/chem.201403974

• Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

  Chemical Science · 2015 · 10.1039/c4sc03905j

• Tris‐Functionalized Hybrid Anderson Polyoxometalates: Synthesis, Characterization, Hydrolytic Stability and Inversion of Protein Surface Charge

  Chemistry - A European Journal · 2015 · 10.1002/chem.201405644

• A Novel Class of Bis- and Tris-Chelate Diam(m)inebis(dicarboxylato)platinum(IV) Complexes as Potential Anticancer Prodrugs

  Journal of Medicinal Chemistry · 2014 · 10.1021/jm500791c

• Improved reaction conditions for the synthesis of new NKP-1339 derivatives and preliminary investigations on their anticancer potential

  Dalton Transactions · 2014 · 10.1039/c4dt01645a

• Antitumor pentamethylcyclopentadienyl rhodium complexes of maltol and allomaltol: Synthesis, solution speciation and bioactivity

  Journal of Inorganic Biochemistry · 2014 · 10.1016/j.jinorgbio.2014.01.020

• Hypothalamic miR-103 Protects from Hyperphagic Obesity in Mice

  Journal of Neuroscience · 2014 · 10.1523/jneurosci.4251-13.2014

• Tumor‐Targeting of EGFR Inhibitors by Hypoxia‐Mediated Activation

  Angewandte Chemie International Edition · 2014 · 10.1002/anie.201403936

• Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

  Chemical Communications · 2013 · 10.1039/c3cc40432c

• Theoretical Investigations and Density Functional Theory Based Quantitative Structure–Activity Relationships Model for Novel Cytotoxic Platinum(IV) Complexes

  Journal of Medicinal Chemistry · 2012 · 10.1021/jm3016427

• A SAR Study of Novel Antiproliferative Ruthenium and Osmium Complexes with Quinoxalinone Ligands in Human Cancer Cell Lines

  Journal of Medicinal Chemistry · 2012 · 10.1021/jm3000906

• Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin

  European Journal of Medicinal Chemistry · 2011 · 10.1016/j.ejmech.2011.09.006

• Impact of Metal Coordination on Cytotoxicity of 3-Aminopyridine-2-carboxaldehyde Thiosemicarbazone (Triapine) and Novel Insights into Terminal Dimethylation

  Journal of Medicinal Chemistry · 2009 · 10.1021/jm900528d

• Gallium(III) and Iron(III) Complexes of α-N-Heterocyclic Thiosemicarbazones: Synthesis, Characterization, Cytotoxicity, and Interaction with Ribonucleotide Reductase

  Journal of Medicinal Chemistry · 2007 · 10.1021/jm0612618

• An Entry to Novel Platinum Complexes: Carboxylation of Dihydroxoplatinum(IV) Complexes with Succinic Anhydride and Subsequent Derivatization

  European Journal of Inorganic Chemistry · 2006 · 10.1002/ejic.200600108

Current projects

No projects listed.