Helmut Klocker

Research interests

Publications

• Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer

  Molecular Cancer · 2022 · 10.1186/s12943-022-01597-7

• The Glucocorticoid Receptor Is a Key Player for Prostate Cancer Cell Survival and a Target for Improved Antiandrogen Therapy

  Clinical Cancer Research · 2017 · 10.1158/1078-0432.ccr-17-0989

• Epithelial-to-Mesenchymal Transition Leads to Docetaxel Resistance in Prostate Cancer and Is Mediated by Reduced Expression of miR-200c and miR-205

  American Journal Of Pathology · 2012 · 10.1016/j.ajpath.2012.08.011

• Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway

  Carcinogenesis · 2012 · 10.1093/carcin/bgs022

• Targeted high throughput sequencing in clinical cancer Settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity

  BMC Medical Genomics · 2011 · 10.1186/1755-8794-4-68

• Prostate-Specific Antigen (PSA) Isoform p2PSA in Combination with Total PSA and Free PSA Improves Diagnostic Accuracy in Prostate Cancer Detection

  European Urology · 2010 · 10.1016/j.eururo.2010.02.003

• Nanoparticle-based bio-barcode assay redefines “undetectable” PSA and biochemical recurrence after radical prostatectomy

  Proceedings of the National Academy of Sciences · 2009 · https://doi.org/10.1073/pnas.0904719106

• Circulating Tumor-Specific DNA: A Marker for Monitoring Efficacy of Adjuvant Therapy in Cancer Patients

  Cancer Research · 2005 · 10.1158/0008-5472.can-04-2438

• SERUM PRO-PROSTATE SPECIFIC ANTIGEN PREFERENTIALLY DETECTS AGGRESSIVE PROSTATE CANCERS IN MEN WITH 2 TO 4 NG/ML PROSTATE SPECIFIC ANTIGEN

  The Journal of Urology · 2004 · 10.1097/01.ju.0000127737.94221.3e

• Serum Pro Prostate Specific Antigen Improves Cancer Detection Compared to Free and Complexed Prostate Specific Antigen in Men With Prostate Specific Antigen 2 to 4 Ng/Ml

  The Journal of Urology · 2003 · 10.1097/01.ju.0000095460.12999.43

• Androgen receptors in prostate cancer.

  Endocrine Related Cancer · 2002 · 10.1677/erc.0.0090155

• Prostate cancer mortality after introduction of prostate-specific antigen mass screening in the Federal State of Tyrol, Austria

  Urology · 2001 · https://doi.org/10.1016/s0090-4295(01)01264-x

• Inhibition of LNCaP prostate cancer cells by means of androgen receptor antisense oligonucleotides

  Cancer Gene Therapy · 2000 · 10.1038/sj.cgt.7700202

• Dihydrotestosterone and the Concept of 5α–Reductase Inhibition in Human Benign Prostatic Hyperplasia

  European Urology · 2000 · 10.1159/000020181

• Immunohistochemical localization of interleukin-6 and its receptor in benign, premalignant and malignant prostate tissue

  The Journal of Pathology · 2000 · 10.1002/1096-9896(2000)9999:9999<::aid-path633>3.0.co;2-x

• Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines.

  PubMed · 1999

• Rapid signalling by androgen receptor in prostate cancer cells

  Oncogene · 1999 · 10.1038/sj.onc.1203032

• CELLULAR AND HUMORAL IMMUNE RESPONSES IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA AFTER VACCINATION WITH ANTIGEN PULSED DENDRITIC CELLS

  The Journal of Urology · 1999 · 10.1016/s0022-5347(01)61767-1

• Switch from antagonist to agonist of the androgen receptor blocker bicalutamide is associated with prostate tumour progression in a new model system

  British Journal of Cancer · 1999 · https://doi.org/10.1038/sj.bjc.6690684

• Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor.

  PubMed · 1998

• Prostaglandin E2 and Tumor Necrosis Factor α Cooperate to Activate Human Dendritic Cells: Synergistic Activation of Interleukin 12 Production

  The Journal of Experimental Medicine · 1997 · 10.1084/jem.186.9.1603

• Androgen Receptor-Ets Protein Interaction Is a Novel Mechanism for Steroid Hormone-mediated Down-modulation of Matrix Metalloproteinase Expression

  Journal of Biological Chemistry · 1996 · 10.1074/jbc.271.39.23907

• Regulation of prostatic growth and function by peptide growth factors

  The Prostate · 1996 · 10.1002/(sici)1097-0045(199606)28:6<392::aid-pros9>3.0.co;2-c

• Distant metastases from prostatic carcinoma express androgen receptor protein.

  PubMed · 1995

• Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone.

  Molecular Endocrinology · 1993 · https://doi.org/10.1210/mend.7.12.8145761

Current projects

No projects listed.