Mathias Müller

Research interests

Publications

• A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription

  Nature Communications · 2019 · 10.1038/s41467-019-10970-y

• Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.09.053

• Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer

  Leukemia · 2018 · 10.1038/s41375-018-0117-x

• Canonical and Non-Canonical Aspects of JAK–STAT Signaling: Lessons from Interferons for Cytokine Responses

  Frontiers in Immunology · 2017 · 10.3389/fimmu.2017.00029

• Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression

  Nature Immunology · 2017 · 10.1038/ni.3655

• The good and the bad faces of STAT1 in solid tumours

  Cytokine · 2015 · 10.1016/j.cyto.2015.11.011

• The regulation of inflammation by interferons and their STATs

  JAK-STAT · 2013 · 10.4161/jkst.23820

• Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

  Nature Medicine · 2013 · 10.1038/nm.3424

• CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response

  Immunity · 2013 · 10.1016/j.immuni.2012.10.017

• Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis

  The ISME Journal · 2012 · 10.1038/ismej.2012.39

• Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis

  PLoS Biology · 2011 · 10.1371/journal.pbio.1000598

• IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA

  Nature Immunology · 2011 · 10.1038/ni.2048

• The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

  Immunity · 2008 · https://doi.org/10.1016/j.immuni.2008.08.012

• Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720

  Blood · 2005 · 10.1182/blood-2005-07-2628

• The Yin and Yang of type I interferon activity in bacterial infection

  Nature reviews. Immunology · 2005 · 10.1038/nri1684

• Phosphorylation of the Stat1 Transactivation Domain Is Required for Full-Fledged IFN-γ-Dependent Innate Immunity

  Immunity · 2003 · 10.1016/s1074-7613(03)00322-4

• Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

  Nature Immunology · 2003 · 10.1038/ni910

• IFNs and STATs in innate immunity to microorganisms

  Journal of Clinical Investigation · 2002 · 10.1172/jci15770

• Partial Impairment of Cytokine Responses in Tyk2-Deficient Mice

  Immunity · 2000 · https://doi.org/10.1016/s1074-7613(00)00054-6

• Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis

  Cell · 1998 · 10.1016/s0092-8674(00)81168-x

• Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling.

  The Journal of Experimental Medicine · 1996 · 10.1084/jem.183.5.2367

• Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon‐alpha and ‐gamma signal transduction pathways.

  The EMBO Journal · 1993 · 10.1002/j.1460-2075.1993.tb06106.x

• Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

  Nature · 1993 · 10.1038/366166a0

• The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

  Nature · 1993 · 10.1038/366129a0

• High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons.

  Proceedings of the National Academy of Sciences · 1991 · 10.1073/pnas.88.24.11455

Current projects

No projects listed.