Matthias Ernst

Research interests

Publications

• IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-019-10676-1

• Targeting Macrophages in Cancer: From Bench to Bedside

  Frontiers in Oncology · 2018 · https://doi.org/10.3389/fonc.2018.00049

• Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map

  Nature reviews. Cancer · 2018 · https://doi.org/10.1038/s41568-018-0090-8

• Targeting JAK kinase in solid tumors: emerging opportunities and challenges

  Oncogene · 2015 · https://doi.org/10.1038/onc.2015.150

• RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

  Cell · 2014 · https://doi.org/10.1016/j.cell.2014.04.019

• Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically

  Cancer Cell · 2013 · https://doi.org/10.1016/j.ccr.2013.06.017

• IL-6 Trans-Signaling Modulates TLR4-Dependent Inflammatory Responses via STAT3

  The Journal of Immunology · 2010 · https://doi.org/10.4049/jimmunol.1002971

• Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

  Cell Division · 2010 · https://doi.org/10.1186/1747-1028-5-14

• gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

  Cancer Cell · 2009 · https://doi.org/10.1016/j.ccr.2009.01.002

• IL-6 Regulates Neutrophil Trafficking during Acute Inflammation via STAT3

  The Journal of Immunology · 2008 · https://doi.org/10.4049/jimmunol.181.3.2189

• STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice

  Journal of Clinical Investigation · 2008 · https://doi.org/10.1172/jci34944

• Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

  Nature Immunology · 2007 · https://doi.org/10.1038/ni1537

• General Nature of the STAT3-Activated Anti-Inflammatory Response

  The Journal of Immunology · 2006 · https://doi.org/10.4049/jimmunol.177.11.7880

• Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system

  Nature Immunology · 2006 · https://doi.org/10.1038/ni1376

• CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK

  Nature Medicine · 2006 · https://doi.org/10.1038/nm1383

• STAT3 Is Required for IL-6-gp130–Dependent Activation of Hepcidin In Vivo

  Gastroenterology · 2006 · https://doi.org/10.1053/j.gastro.2006.10.018

• IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation

  Proceedings of the National Academy of Sciences · 2005 · https://doi.org/10.1073/pnas.0501794102

• Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling

  Nature Medicine · 2005 · https://doi.org/10.1038/nm1282

• Acquiring signalling specificity from the cytokine receptor gp130

  Trends in Genetics · 2003 · https://doi.org/10.1016/j.tig.2003.11.003

• Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

  Nature Medicine · 2002 · https://doi.org/10.1038/nm763

• LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival

  Nature Medicine · 2002 · https://doi.org/10.1038/nm0602-613

• Defective Gp130-Mediated Signal Transducer and Activator of Transcription (Stat) Signaling Results in Degenerative Joint Disease, Gastrointestinal Ulceration, and Failure of Uterine Implantation

  The Journal of Experimental Medicine · 2001 · https://doi.org/10.1084/jem.194.2.189

• Estradiol Effects on Proliferation, Messenger Ribonucleic Acid for Collagen and Insulin-like Growth Factor-I, and Parathyroid Hormone-Stimulated Adenylate Cyclase Activity in Osteoblastic Cells from Calvariae and Long Bones

  Endocrinology · 1989 · https://doi.org/10.1210/endo-125-2-825

• Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local synthesis of insulin-like growth factor I

  Biochemical and Biophysical Research Communications · 1988 · https://doi.org/10.1016/0006-291x(88)90570-0

• Enhanced osteoblast proliferation and collagen gene expression by estradiol.

  Proceedings of the National Academy of Sciences · 1988 · https://doi.org/10.1073/pnas.85.7.2307

Current projects

No projects listed.