Grainne M. O’Kane

Research interests

Publications

• Efficacy of Zenocutuzumab in NRG1 Fusion–Positive Cancer

  New England Journal of Medicine · 2025 · 10.1056/nejmoa2405008

• Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

  Immunity · 2022 · https://doi.org/10.1016/j.immuni.2022.01.006

• Efficacy and safety of zenocutuzumab, a HER2 x HER3 bispecific antibody, across advanced NRG1 fusion (NRG1+) cancers.

  Journal of Clinical Oncology · 2022 · 10.1200/jco.2022.40.16_suppl.105

• Dynamic risk profiling of HCC recurrence after curative intent liver resection

  Hepatology · 2022 · 10.1002/hep.32411

• Spatially confined sub-tumor microenvironments in pancreatic cancer

  Cell · 2021 · 10.1016/j.cell.2021.09.022

• Genomic Features and Classification of Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma

  Gastroenterology · 2021 · 10.1053/j.gastro.2021.01.220

• Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0566-9

• GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer

  Clinical Cancer Research · 2020 · 10.1158/1078-0432.ccr-19-3724

• Clinical and genomic characterisation of mismatch repair deficient pancreatic adenocarcinoma

  Gut · 2020 · 10.1136/gutjnl-2020-320730

• A Four-Chemokine Signature Is Associated with a T-cell–Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer

  Clinical Cancer Research · 2020 · 10.1158/1078-0432.ccr-19-2803

• Subtype-Discordant Pancreatic Ductal Adenocarcinoma Tumors Show Intermediate Clinical and Molecular Characteristics

  Clinical Cancer Research · 2020 · 10.1158/1078-0432.ccr-20-2831

• A phase 2 trial of sunitinib in patients with progressive paraganglioma or pheochromocytoma: the SNIPP trial

  British Journal of Cancer · 2019 · 10.1038/s41416-019-0474-x

• Morphological classification of pancreatic ductal adenocarcinoma that predicts molecular subtypes and correlates with clinical outcome

  Gut · 2019 · 10.1136/gutjnl-2019-318217

• Altered Gene Expression along the Glycolysis–Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer

  Clinical Cancer Research · 2019 · 10.1158/1078-0432.ccr-19-1543

• Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases

  Cancer Cell · 2019 · https://doi.org/10.1016/j.ccell.2018.12.010

• Sensitive tumour detection and classification using plasma cell-free DNA methylomes

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0703-0

• Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

  Cancer Discovery · 2018 · https://doi.org/10.1158/2159-8290.cd-18-0349

• EGFR -Mutant Adenocarcinomas That Transform to Small-Cell Lung Cancer and Other Neuroendocrine Carcinomas: Clinical Outcomes

  Journal of Clinical Oncology · 2018 · 10.1200/jco.18.01585

• Uncommon EGFR mutations in advanced non-small cell lung cancer

  Lung Cancer · 2017 · 10.1016/j.lungcan.2017.04.016

• A national stakeholder consensus study of challenges and priorities for clinical learning environments in postgraduate medical education

  BMC Medical Education · 2017 · 10.1186/s12909-017-1065-2

• Characterization, Detection, and Treatment Approaches for Homologous Recombination Deficiency in Cancer

  Trends in Molecular Medicine · 2017 · 10.1016/j.molmed.2017.10.007

• Third-Generation Tyrosine Kinase Inhibitors Targeting Epidermal Growth Factor Receptor Mutations in Non-Small Cell Lung Cancer

  Frontiers in Oncology · 2017 · 10.3389/fonc.2017.00113

• Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial

  Clinical Cancer Research · 2017 · https://doi.org/10.1158/1078-0432.ccr-17-2994

• Monitoring and Management of Immune-Related Adverse Events Associated With Programmed Cell Death Protein-1 Axis Inhibitors in Lung Cancer

  The Oncologist · 2016 · 10.1634/theoncologist.2016-0164

• Perioperative chemotherapy in the treatment of osteosarcoma: a 26-year single institution review

  Clinical Sarcoma Research · 2015 · 10.1186/s13569-015-0032-0

Current projects

No projects listed.