Paul S. Donnelly

Research interests

Publications

• Harnessing 64 Cu/ 67 Cu for a theranostic approach to pretargeted radioimmunotherapy

  Proceedings of the National Academy of Sciences · 2020 · https://doi.org/10.1073/pnas.2009960117

• CuII(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease

  British Journal of Pharmacology · 2019 · https://doi.org/10.1111/bph.14881

• A conceptual framework for the development of iridium( iii ) complex-based electrogenerated chemiluminescence labels

  Chemical Science · 2019 · https://doi.org/10.1039/c9sc01391a

• 64Cu-SARTATE PET Imaging of Patients with Neuroendocrine Tumors Demonstrates High Tumor Uptake and Retention, Potentially Allowing Prospective Dosimetry for Peptide Receptor Radionuclide Therapy

  Journal of Nuclear Medicine · 2018 · https://doi.org/10.2967/jnumed.118.217745

• Engineering Poly(ethylene glycol) Particles for Improved Biodistribution

  ACS Nano · 2015 · https://doi.org/10.1021/nn5061578

• Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease

  Chemical Society Reviews · 2014 · https://doi.org/10.1039/c4cs00026a

• Oral Treatment with CuII(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

  Journal of Neuroscience · 2014 · https://doi.org/10.1523/jneurosci.4196-13.2014

• Increasing Intracellular Bioavailable Copper Selectively Targets Prostate Cancer Cells

  ACS Chemical Biology · 2013 · https://doi.org/10.1021/cb400198p

• The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease

  The Journal of Experimental Medicine · 2012 · https://doi.org/10.1084/jem.20112285

• Comparison of 64 Cu-Complexing Bifunctional Chelators for Radioimmunoconjugation: Labeling Efficiency, Specific Activity, and in Vitro / in Vivo Stability

  Bioconjugate Chemistry · 2012 · https://doi.org/10.1021/bc300037w

• Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model

  Journal of Biological Chemistry · 2011 · https://doi.org/10.1074/jbc.m111.274407

• The Alzheimer’s therapeutic PBT2 promotes amyloid‐β degradation and GSK3 phosphorylation via a metal chaperone activity

  Journal of Neurochemistry · 2011 · https://doi.org/10.1111/j.1471-4159.2011.07402.x

• Copper complexes of bis(thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals

  Chemical Society Reviews · 2011 · https://doi.org/10.1039/c0cs00215a

• Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation

  Proceedings of the National Academy of Sciences · 2009 · https://doi.org/10.1073/pnas.0809057106

• Transfer of Copper between Bis(thiosemicarbazone) Ligands and Intracellular Copper-Binding Proteins. Insights into Mechanisms of Copper Uptake and Hypoxia Selectivity

  Inorganic Chemistry · 2008 · https://doi.org/10.1021/ic702440e

• ‘Click’ cycloaddition catalysts: copper(i) and copper(ii) tris(triazolylmethyl)amine complexes

  Chemical Communications · 2008 · https://doi.org/10.1039/b719724a

• Copper and Alzheimer's disease

  Current Opinion in Chemical Biology · 2007 · https://doi.org/10.1016/j.cbpa.2007.01.678

• Selective Intracellular Release of Copper and Zinc Ions from Bis(thiosemicarbazonato) Complexes Reduces Levels of Alzheimer Disease Amyloid-β Peptide

  Journal of Biological Chemistry · 2007 · https://doi.org/10.1074/jbc.m705957200

• Functionalized Bis(thiosemicarbazonato) Complexes of Zinc and Copper: Synthetic Platforms Toward Site-Specific Radiopharmaceuticals

  Inorganic Chemistry · 2006 · https://doi.org/10.1021/ic0615628

• Sport and Festival in the Ancient Greek World

  Journal · 2003 · https://doi.org/10.2307/j.ctv1n357mz

• Structural trends in copper( ii ) bis(thiosemicarbazone) radiopharmaceuticals

  Dalton Transactions · 2003 · https://doi.org/10.1039/b307499d

• An Unusual Dimeric Structure of a Cu(I) Bis(thiosemicarbazone) Complex: Implications for the Mechanism of Hypoxic Selectivity of the Cu(II) Derivatives

  Journal of the American Chemical Society · 2002 · https://doi.org/10.1021/ja012668z

Current projects

No projects listed.