Leonie S. Young

Research interests

Publications

• Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities

  Nature Communications · 2022 · 10.1038/s41467-022-27987-5

• Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

  Nature Medicine · 2022 · 10.1038/s41591-022-01749-8

• Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities

  Nature Communications · 2022 · 10.1038/s41467-022-27987-5

• Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines

  Cancer Research · 2020 · https://doi.org/10.1158/0008-5472.can-20-0291

• Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable Targets

  JNCI Journal of the National Cancer Institute · 2018 · https://doi.org/10.1093/jnci/djy110

• The Women’s wellness after cancer program: a multisite, single-blinded, randomised controlled trial protocol

  BMC Cancer · 2017 · 10.1186/s12885-017-3088-9

• Intrinsic Subtype Switching and Acquired ERBB2/HER2 Amplifications and Mutations in Breast Cancer Brain Metastases

  JAMA Oncology · 2016 · 10.1001/jamaoncol.2016.5630

• CD44 increases the efficiency of distant metastasis of breast cancer

  Oncotarget · 2015 · https://doi.org/10.18632/oncotarget.3410

• Epigenetic Reprogramming of HOXC10 in Endocrine-Resistant Breast Cancer

  Science Translational Medicine · 2014 · 10.1126/scitranslmed.3008326

• Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

  Breast Cancer Research · 2013 · https://doi.org/10.1186/bcr3493

• The Function of Steroid Receptor Coactivator-1 in Normal Tissues and Cancer

  International Journal of Biological Sciences · 2012 · https://doi.org/10.7150/ijbs.4125

• Metastatic Progression with Resistance to Aromatase Inhibitors Is Driven by the Steroid Receptor Coactivator SRC-1

  Cancer Research · 2011 · 10.1158/0008-5472.can-11-2073

• Interaction of Developmental Transcription Factor HOXC11 with Steroid Receptor Coactivator SRC-1 Mediates Resistance to Endocrine Therapy in Breast Cancer

  Cancer Research · 2010 · 10.1158/0008-5472.can-09-3713

• Coassociation of Estrogen Receptor and p160 Proteins Predicts Resistance to Endocrine Treatment; SRC-1 is an Independent Predictor of Breast Cancer Recurrence

  Clinical Cancer Research · 2009 · 10.1158/1078-0432.ccr-08-1649

• Coassociation of Estrogen Receptor and p160 Proteins Predicts Resistance to Endocrine Treatment; SRC-1 is an Independent Predictor of Breast Cancer Recurrence

  Clinical Cancer Research · 2009 · 10.1158/1078-0432.ccr-08-1649

• The AIB1 Oncogene Promotes Breast Cancer Metastasis by Activation of PEA3-Mediated Matrix Metalloproteinase 2 (MMP2) and MMP9 Expression

  Molecular and Cellular Biology · 2008 · 10.1128/mcb.00579-08

• Growth factor-dependent regulation of survivin by c-myc in human breast cancer

  Journal of Molecular Endocrinology · 2006 · 10.1677/jme.1.02118

• Associations and Interactions between Ets-1 and Ets-2 and Coregulatory Proteins, SRC-1, AIB1, and NCoR in Breast Cancer

  Clinical Cancer Research · 2005 · https://doi.org/10.1158/1078-0432.ccr-04-1192

• Inverse relationship between ER-β and SRC-1 predicts outcome in endocrine-resistant breast cancer

  British Journal of Cancer · 2004 · 10.1038/sj.bjc.6602156

• Inverse relationship between ER-β and SRC-1 predicts outcome in endocrine-resistant breast cancer

  British Journal of Cancer · 2004 · 10.1038/sj.bjc.6602156

• Differential Recruitment of Coregulator Proteins Steroid Receptor Coactivator-1 and Silencing Mediator for Retinoid and Thyroid Receptors to the Estrogen Receptor-Estrogen Response Element by β-Estradiol and 4-Hydroxytamoxifen in Human Breast Cancer

  The Journal of Clinical Endocrinology & Metabolism · 2004 · 10.1210/jc.2003-031048

• Differential Recruitment of Coregulator Proteins Steroid Receptor Coactivator-1 and Silencing Mediator for Retinoid and Thyroid Receptors to the Estrogen Receptor-Estrogen Response Element by β-Estradiol and 4-Hydroxytamoxifen in Human Breast Cancer

  The Journal of Clinical Endocrinology & Metabolism · 2004 · 10.1210/jc.2003-031048

• Expression of SRC-1, AIB1, and PEA3 in HER2 mediated endocrine resistant breast cancer; a predictive role for SRC-1

  Journal of Clinical Pathology · 2004 · https://doi.org/10.1136/jcp.2004.016733

• Hypothalamo-Pituitary-Adrenal Axis Dysfunction in Chronic Fatigue Syndrome, and the Effects of Low-Dose Hydrocortisone Therapy

  The Journal of Clinical Endocrinology & Metabolism · 2001 · https://doi.org/10.1210/jcem.86.8.7735

Current projects

No projects listed.