Nicholas A. Kennedy

Research interests

Publications

• A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial

  ˜The œLancet. Gastroenterology & hepatology · 2024 · https://doi.org/10.1016/s2468-1253(24)00034-7

• A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial

  ˜The œLancet. Gastroenterology & hepatology · 2024 · https://doi.org/10.1016/s2468-1253(24)00034-7

• Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00950-8

• Response to SARS-CoV-2 vaccination in immune mediated inflammatory diseases: Systematic review and meta-analysis

  Autoimmunity Reviews · 2021 · https://doi.org/10.1016/j.autrev.2021.102927

• British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic

  Gut · 2020 · https://doi.org/10.1136/gutjnl-2020-321244

• British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults

  Gut · 2019 · https://doi.org/10.1136/gutjnl-2019-318484

• HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn’s Disease

  Gastroenterology · 2019 · https://doi.org/10.1053/j.gastro.2019.09.041

• Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

  ˜The œLancet. Gastroenterology & hepatology · 2019 · https://doi.org/10.1016/s2468-1253(19)30012-3

• IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-04365-8

• Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases

  Gastroenterology · 2018 · https://doi.org/10.1053/j.gastro.2018.01.002

• Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3760

• Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms13507

• Inflammatory Bowel Disease Associates with Proinflammatory Potential of the Immunoglobulin G Glycome

  Inflammatory Bowel Diseases · 2015 · https://doi.org/10.1097/mib.0000000000000372

• Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

  The Lancet · 2015 · https://doi.org/10.1016/s0140-6736(15)00465-1

• The role of glycosylation in IBD

  Nature Reviews Gastroenterology & Hepatology · 2014 · https://doi.org/10.1038/nrgastro.2014.78

• The Impact of Different DNA Extraction Kits and Laboratories upon the Assessment of Human Gut Microbiota Composition by 16S rRNA Gene Sequencing

  PLoS ONE · 2014 · https://doi.org/10.1371/journal.pone.0088982

• Beyond Gene Discovery in Inflammatory Bowel Disease: The Emerging Role of Epigenetics

  Gastroenterology · 2013 · https://doi.org/10.1053/j.gastro.2013.05.050

Current projects

No projects listed.