David C. Henshall

Research interests

Publications

• Microvascular stabilization via blood-brain barrier regulation prevents seizure activity

  Nature Communications · 2022 · https://doi.org/10.1038/s41467-022-29657-y

• LifeTime and improving European healthcare through cell-based interceptive medicine

  Nature · 2020 · https://doi.org/10.1038/s41586-020-2715-9

• MicroRNAs as regulators of brain function and targets for treatment of epilepsy

  Nature Reviews Neurology · 2020 · https://doi.org/10.1038/s41582-020-0369-8

• Neuroinflammatory targets and treatments for epilepsy validated in experimental models

  Epilepsia · 2017 · https://doi.org/10.1111/epi.13783

• The Epigenetics of Epilepsy and Its Progression

  The Neuroscientist · 2017 · 10.1177/1073858417705840

• MicroRNAs in epilepsy: pathophysiology and clinical utility

  The Lancet Neurology · 2016 · https://doi.org/10.1016/s1474-4422(16)30246-0

• Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

  Journal of Neuroscience · 2016 · https://doi.org/10.1523/jneurosci.4009-15.2016

• Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy

  Brain · 2014 · https://doi.org/10.1093/brain/awu373

• Increased neocortical expression of the P 2X7 receptor after status epilepticus and anticonvulsant effect of P 2X7 receptor antagonist A ‐438079

  Epilepsia · 2013 · 10.1111/epi.12257

• Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

  Nature Medicine · 2012 · https://doi.org/10.1038/nm.2834

• Reduced Mature MicroRNA Levels in Association with Dicer Loss in Human Temporal Lobe Epilepsy with Hippocampal Sclerosis

  PLoS ONE · 2012 · 10.1371/journal.pone.0035921

• miRNA Expression Profile after Status Epilepticus and Hippocampal Neuroprotection by Targeting miR-132

  American Journal Of Pathology · 2011 · https://doi.org/10.1016/j.ajpath.2011.07.036

• Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

  The FASEB Journal · 2011 · https://doi.org/10.1096/fj.11-196089

• Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice

  Brain Research · 2008 · https://doi.org/10.1016/j.brainres.2008.03.061

• Endotoxin Preconditioning Protects against the Cytotoxic Effects of TNFα after Stroke: A Novel Role for TNFα in LPS-Ischemic Tolerance

  Journal of Cerebral Blood Flow & Metabolism · 2007 · https://doi.org/10.1038/sj.jcbfm.9600464

• CREB-Mediated Bcl-2 Protein Expression after Ischemic Preconditioning

  Journal of Cerebral Blood Flow & Metabolism · 2005 · https://doi.org/10.1038/sj.jcbfm.9600024

• Epilepsy and Apoptosis Pathways

  Journal of Cerebral Blood Flow & Metabolism · 2005 · https://doi.org/10.1038/sj.jcbfm.9600149

• Endotoxin Preconditioning Prevents Cellular Inflammatory Response During Ischemic Neuroprotection in Mice

  Stroke · 2004 · https://doi.org/10.1161/01.str.0000143450.04438.ae

• Increased hippocampal neurogenesis in Alzheimer's disease

  Proceedings of the National Academy of Sciences · 2003 · https://doi.org/10.1073/pnas.2634794100

• To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways

  Progress in Neurobiology · 2003 · https://doi.org/10.1016/s0301-0082(03)00005-4

• Activation of Bcl-2-Associated Death Protein and Counter-Response of Akt within Cell Populations during Seizure-Induced Neuronal Death

  Journal of Neuroscience · 2002 · https://doi.org/10.1523/jneurosci.22-19-08458.2002

• Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy

  Neurology · 2000 · https://doi.org/10.1212/wnl.55.2.250

• Involvement of Caspase‐3‐Like Protease in the Mechanism of Cell Death Following Focally Evoked Limbic Seizures

  Journal of Neurochemistry · 2000 · 10.1046/j.1471-4159.2000.741215.x

• Induction of Oxidative DNA Damage in the Peri‐Infarct Region After Permanent Focal Cerebral Ischemia

  Journal of Neurochemistry · 2000 · 10.1046/j.1471-4159.2000.0751716.x

• Neuroprotective Actions of FK506 in Experimental Stroke:In VivoEvidence against an Antiexcitotoxic Mechanism

  Journal of Neuroscience · 1997 · https://doi.org/10.1523/jneurosci.17-18-06939.1997

Current projects

No projects listed.