Isabel Santana

Research interests

Publications

• Temporal order of clinical and biomarker changes in familial frontotemporal dementia

  Nature Medicine · 2022 · https://doi.org/10.1038/s41591-022-01942-9

• Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00785-3

• Pathophysiology of Blood–Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery

  Frontiers in Neurology · 2020 · https://doi.org/10.3389/fneur.2020.594672

• Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study

  The Lancet Neurology · 2019 · https://doi.org/10.1016/s1474-4422(19)30354-0

• Clinical validation of the Lumipulse G cerebrospinal fluid assays for routine diagnosis of Alzheimer’s disease

  Alzheimer s Research & Therapy · 2019 · https://doi.org/10.1186/s13195-019-0550-8

• Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study

  The Lancet Neurology · 2019 · https://doi.org/10.1016/s1474-4422(19)30283-2

• Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study

  Alzheimer s & Dementia · 2019 · https://doi.org/10.1016/j.jalz.2019.01.015

• Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study

  The Lancet Neurology · 2017 · https://doi.org/10.1016/s1474-4422(17)30400-3

• Portuguese family with the co-occurrence of frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis phenotypes due to progranulin gene mutation

  Neurobiology of Aging · 2016 · https://doi.org/10.1016/j.neurobiolaging.2016.02.019

• Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study

  Brain · 2016 · https://doi.org/10.1093/brain/aww160

• Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease

  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2015 · https://doi.org/10.1016/j.bbadis.2015.03.015

• Prevalence and prognosis of Alzheimer’s disease at the mild cognitive impairment stage

  Brain · 2015 · https://doi.org/10.1093/brain/awv029

• Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases

  Nature Reviews Neurology · 2014 · https://doi.org/10.1038/nrneurol.2014.232

• Montreal Cognitive Assessment: Influence of Sociodemographic and Health Variables

  Archives of Clinical Neuropsychology · 2012 · https://doi.org/10.1093/arclin/acr116

• A Pan‐ E uropean Study of the C9orf72 Repeat Associated with FTLD : Geographic Prevalence, Genomic Instability, and Intermediate Repeats

  Human Mutation · 2012 · https://doi.org/10.1002/humu.22244

• Montreal Cognitive Assessment (MoCA): Validation Study for Vascular Dementia

  Journal of the International Neuropsychological Society · 2012 · https://doi.org/10.1017/s135561771200077x

• Data mining methods in the prediction of Dementia: A real-data comparison of the accuracy, sensitivity and specificity of linear discriminant analysis, logistic regression, neural networks, support vector machines, classification trees and random forests

  BMC Research Notes · 2011 · https://doi.org/10.1186/1756-0500-4-299

• Montreal Cognitive Assessment (MoCA): Normative study for the Portuguese population

  Journal of Clinical and Experimental Neuropsychology · 2011 · https://doi.org/10.1080/13803395.2011.589374

• Montreal Cognitive Assessment

  Alzheimer Disease & Associated Disorders · 2011 · https://doi.org/10.1097/wad.0b013e3182420bfe

• Construct Validity of the Montreal Cognitive Assessment (MoCA)

  Journal of the International Neuropsychological Society · 2011 · https://doi.org/10.1017/s1355617711001573

• Peripheral Oxidative Damage in Mild Cognitive Impairment and Mild Alzheimer's Disease

  Journal of Alzheimer s Disease · 2008 · https://doi.org/10.3233/jad-2008-15110

• Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP

  Neurobiology of Aging · 2008 · https://doi.org/10.1016/j.neurobiolaging.2008.06.012

• Peripheral Inflammatory Cytokines as Biomarkers in Alzheimer’s Disease and Mild Cognitive Impairment

  Neurodegenerative Diseases · 2007 · https://doi.org/10.1159/000107700

• Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aβ toxicity

  Journal of Neurochemistry · 2004 · https://doi.org/10.1111/j.1471-4159.2004.02438.x

• Cytochrome c oxidase is decreased in Alzheimer’s disease platelets

  Neurobiology of Aging · 2003 · https://doi.org/10.1016/s0197-4580(03)00033-2

Current projects

No projects listed.